Moderate exercise training improves survival and ventricular remodeling in an animal model of left ventricular volume overload.

Authors: Lachance, DominicPlante, ÉricChampetier, SergeRoussel, ÉliseDrolet, Marie-ClaudeArsenault, MarieCouët, Jacques
Abstract: BACKGROUND: Exercise training has beneficial effects in patients with heart failure, although there is still no clear evidence that it may impact on their survival. There are no data regarding the effects of exercise in subjects with chronic left ventricular (LV) volume overload. Using a rat model of severe aortic valve regurgitation (AR), we studied the effects of long-term exercise training on survival, development of heart failure, and LV myocardial remodeling. METHODS AND RESULTS: One hundred sixty male adult rats were divided in 3 groups: sham sedentary (n=40), AR sedentary (n=80), and AR trained (n=40). Training consisted in treadmill running for up to 30 minutes, 5 times per week for 9 months, at a maximal speed of 20 m/minute. All sham-operated animals survived the entire course of the protocol. After 9 months, 65% of trained animals were alive compared with 46% of sedentary ones (P=0.05). Ejection fractions remained in the normal range (all above 60%) and LV masses between AR groups were similar. There was significantly less LV fibrosis in the trained group and lower LV filling pressures and improved echocardiographic diastolic parameters. Heart rate variability was also improved by exercise. CONCLUSIONS: Our data show that moderate endurance training is safe, does not increase the rate of developing heart failure, and most importantly, improves survival in this animal model of chronic LV volume overload. Exercise improved LV diastolic function, heart rate variability, and reduced myocardial fibrosis.
Document Type: Article de recherche
Issue Date: 15 September 2009
Open Access Date: 15 November 2017
Document version: AM
Permalink: http://hdl.handle.net/20.500.11794/15839
This document was published in: Circulation : Heart Failure, Vol. 2 (5), 437–445 (2009)
https://doi.org/10.1161/CIRCHEARTFAILURE.108.845487
Lippincott Williams & Wilkins
Alternative version: 10.1161/CIRCHEARTFAILURE.108.845487
19808374
Collection:Articles publiés dans des revues avec comité de lecture

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