Up-regulation of caveolin expression by cytotoxic agents in drug-sensitive cancer cells

Authors: Bélanger, MartinRoussel, ÉliseCouët, Jacques
Abstract: Caveolin 1 expression is down-regulated in various cancer cell lines. Interestingly, in several drug-resistant cancer cells, a strong induction of caveolin 1 expression has been reported, suggesting a role for caveolin 1 in the acquisition and/or the maintenance of the multidrug-resistance phenotype. Here, we show, in drug-sensitive lung cancer cells (A549, Calu-6 or NCI-H69), that exposure to cytotoxic drugs (taxol, doxorubicin or etoposide) is sufficient to strongly up-regulate caveolin 1 and 2 protein levels. This up-regulation is sustained even 1 week after drug removal. Our results suggest that caveolin up-regulation is an early cellular response to a cytotoxic stress taking place before drug resistance.
Document Type: Article de recherche
Issue Date: 1 April 2003
Open Access Date: 15 November 2017
Document version: AM
Permalink: http://hdl.handle.net/20.500.11794/15832
This document was published in: Anti-cancer drugs, Vol. 14 (4), 281-287 (2003)
Rapid Communications of Oxford
Collection:Articles publiés dans des revues avec comité de lecture

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