Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males

DC FieldValueLanguage
dc.contributor.authorBeaumont, Catherine-
dc.contributor.authorWalsh-Wilkinson, Élisabeth-
dc.contributor.authorDrolet, Marie-Claude-
dc.contributor.authorRoussel, Élise-
dc.contributor.authorArsenault, Marie-
dc.contributor.authorCouët, Jacques-
dc.description.abstractAortic valve regurgitation (AR) imposes a volume overload (VO) to the left ventricle (LV). Male rats with a pathological heart overload usually progress more quickly towards heart failure than females. We examined whether a sexual dimorphism exists in the myocardial transcriptional adaptations to AR. Adult Wistar male and female rats either underwent a sham operation or were induced with AR and then followed for 26 weeks. Female AR rats gained relatively more LV mass than males (75 vs. 42%). They had a similar increase in LV chamber dimensions compared to males but more wall thickening. On the other hand, fatty acid oxidation (FAO)-related LV enzyme activity was only decreased in AR males. The expression of genes encoding FAO-related enzymes was only reduced in AR males and not in females. A similar situation was observed for the expression of genes involved in mitochondrial biogenesis or function as well as for genes encoding for transcription factors implicated in the control of bioenergetics and mitochondrial function (Errα, Errγ or Pgc1α). Although females develop more LV hypertrophy from severe VO, their myocardial gene expression remains closer to normal. This could provide survival benefits for females with severe VO.fr
dc.publisherNature Publishing Groupfr
dc.subjectSex dimorphismfr
dc.subjectVolume overloadfr
dc.subjectAortic valvefr
dc.subjectGene expressionfr
dc.titleFemale rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than malesfr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationScientific Reports, Vol. 7 (1), 1-37 (2017)fr
dc.subject.rvmDimorphisme sexuel chez les animauxfr
dc.subject.rvmRats (Animaux de laboratoire)fr
dc.subject.rvmCœur -- Ventricule gauche -- Maladiesfr
dc.subject.rvmCœur -- Hypertrophiefr
dc.subject.rvmTranscription génétiquefr
dc.subject.rvmExpression géniquefr
dc.subject.rvmInsuffisance cardiaquefr
dc.subject.rvmValve aortiquefr
rioxxterms.versionAccepted Manuscriptfr
ali.license_refAttribution CC BYfr
bul.rights.periodeEmbargo0 moisfr
Collection:Articles publiés dans des revues avec comité de lecture

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