Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males

Auteur(s): Beaumont, CatherineWalsh-Wilkinson, ÉlisabethDrolet, Marie-ClaudeRoussel, ÉliseArsenault, MarieCouët, Jacques
Résumé: Aortic valve regurgitation (AR) imposes a volume overload (VO) to the left ventricle (LV). Male rats with a pathological heart overload usually progress more quickly towards heart failure than females. We examined whether a sexual dimorphism exists in the myocardial transcriptional adaptations to AR. Adult Wistar male and female rats either underwent a sham operation or were induced with AR and then followed for 26 weeks. Female AR rats gained relatively more LV mass than males (75 vs. 42%). They had a similar increase in LV chamber dimensions compared to males but more wall thickening. On the other hand, fatty acid oxidation (FAO)-related LV enzyme activity was only decreased in AR males. The expression of genes encoding FAO-related enzymes was only reduced in AR males and not in females. A similar situation was observed for the expression of genes involved in mitochondrial biogenesis or function as well as for genes encoding for transcription factors implicated in the control of bioenergetics and mitochondrial function (Errα, Errγ or Pgc1α). Although females develop more LV hypertrophy from severe VO, their myocardial gene expression remains closer to normal. This could provide survival benefits for females with severe VO.
Type de document: Article de recherche
Date de publication: 7 avril 2017
Date de la mise en libre accès: 13 novembre 2017
Version du document: AM
Licence Creative Commons: https://creativecommons.org/licenses/by/4.0
Lien permanent: http://hdl.handle.net/20.500.11794/15822
Ce document a été publié dans: Scientific Reports, Vol. 7 (1), 1-37 (2017)
Nature Publishing Group
Autre version disponible: 10.1038/s41598-017-00855-9
Collection :Articles publiés dans des revues avec comité de lecture

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