Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males

Authors: Beaumont, CatherineWalsh-Wilkinson, ÉlisabethDrolet, Marie-ClaudeRoussel, ÉliseArsenault, MarieCouët, Jacques
Abstract: Aortic valve regurgitation (AR) imposes a volume overload (VO) to the left ventricle (LV). Male rats with a pathological heart overload usually progress more quickly towards heart failure than females. We examined whether a sexual dimorphism exists in the myocardial transcriptional adaptations to AR. Adult Wistar male and female rats either underwent a sham operation or were induced with AR and then followed for 26 weeks. Female AR rats gained relatively more LV mass than males (75 vs. 42%). They had a similar increase in LV chamber dimensions compared to males but more wall thickening. On the other hand, fatty acid oxidation (FAO)-related LV enzyme activity was only decreased in AR males. The expression of genes encoding FAO-related enzymes was only reduced in AR males and not in females. A similar situation was observed for the expression of genes involved in mitochondrial biogenesis or function as well as for genes encoding for transcription factors implicated in the control of bioenergetics and mitochondrial function (Errα, Errγ or Pgc1α). Although females develop more LV hypertrophy from severe VO, their myocardial gene expression remains closer to normal. This could provide survival benefits for females with severe VO.
Document Type: Article de recherche
Issue Date: 7 April 2017
Open Access Date: 13 November 2017
Document version: AM
Creative Commons Licence: https://creativecommons.org/licenses/by/4.0
Permalink: http://hdl.handle.net/20.500.11794/15822
This document was published in: Scientific Reports, Vol. 7 (1), 1-37 (2017)
https://doi.org/10.1038/s41598-017-00855-9
Nature Publishing Group
Alternative version: 10.1038/s41598-017-00855-9
Collection:Articles publiés dans des revues avec comité de lecture

Files in this item:
Description SizeFormat 
128366_1_merged_1484831950.pdf1.78 MBAdobe PDFView/Open
Suppl tableRR.pdf116.52 kBAdobe PDFView/Open
All documents in CorpusUL are protected by Copyright Act of Canada.