Transcriptional changes associated with long-term left ventricle volume overload in rats : impact on enzymes related to myocardial energy metabolism.

DC FieldValueLanguage
dc.contributor.authorRoussel, Élise-
dc.contributor.authorDrolet, Marie-Claude-
dc.contributor.authorWalsh-Wilkinson, Élisabeth-
dc.contributor.authorDhahri, Wahiba-
dc.contributor.authorLachance, Dominic-
dc.contributor.authorGascon, Suzanne-
dc.contributor.authorSarrhini, Otman-
dc.contributor.authorRousseau, Jacques A.-
dc.contributor.authorLecomte, Roger-
dc.contributor.authorCouët, Jacques-
dc.contributor.authorArsenault, Marie-
dc.date.accessioned2017-11-13T13:46:58Z-
dc.date.available2017-11-13T13:46:58Z-
dc.date.issued2015-10-25-
dc.identifier.issn2314-6141fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/15821-
dc.description.abstractPatients with left ventricle (LV) volume overload (VO) remain in a compensated state for many years although severe dilation is present. The myocardial capacity to fulfill its energetic demand may delay decompensation. We performed a gene expression profile, a model of chronic VO in rat LV with severe aortic valve regurgitation (AR) for 9 months, and focused on the study of genes associated with myocardial energetics. Methods. LV gene expression profile was performed in rats after 9 months of AR and compared to sham-operated controls. LV glucose and fatty acid (FA) uptake was also evaluated in vivo by positron emission tomography in 8-week AR rats treated or not with fenofibrate, an activator of FA oxidation (FAO). Results. Many LV genes associated with mitochondrial function and metabolism were downregulated in AR rats. FA β-oxidation capacity was significantly impaired as early as two weeks after AR. Treatment with fenofibrate, a PPARα agonist, normalized both FA and glucose uptake while reducing LV dilation caused by AR. Conclusion. Myocardial energy substrate preference is affected early in the evolution of LV-VO cardiomyopathy. Maintaining a relatively normal FA utilization in the myocardium could translate into less glucose uptake and possibly lesser LV remodeling.fr
dc.languageengfr
dc.publisherHindawifr
dc.titleTranscriptional changes associated with long-term left ventricle volume overload in rats : impact on enzymes related to myocardial energy metabolism.fr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationBioMed Research International, Vol. 2015, (2015)fr
dc.identifier.doi10.1155/2015/949624fr
dc.identifier.pubmedPMC4637065fr
dc.subject.rvmCœur -- Ventricule gauche -- Maladiesfr
dc.subject.rvmRats (Animaux de laboratoire)fr
dc.subject.rvmExpression géniquefr
dc.subject.rvmMyocardefr
dc.subject.rvmTranscription génétiquefr
rioxxterms.versionAccepted Manuscriptfr
rioxxterms.version_of_recordhttps://doi.org/10.1155/2015/949624fr
rioxxterms.project.funder_nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder_nameHeart and Stroke Foundation of Canadafr
rioxxterms.project.funder_nameQuebec Heart Institute Corporationfr
bul.rights.periodeEmbargo0 moisfr
Collection:Articles publiés dans des revues avec comité de lecture

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