Transcriptional changes associated with long-term left ventricle volume overload in rats : impact on enzymes related to myocardial energy metabolism.
|Authors:||Roussel, Élise; Drolet, Marie-Claude; Walsh-Wilkinson, Élisabeth; Dhahri, Wahiba; Lachance, Dominic; Gascon, Suzanne; Sarrhini, Otman; Rousseau, Jacques A.; Lecomte, Roger; Couët, Jacques; Arsenault, Marie|
|Abstract:||Patients with left ventricle (LV) volume overload (VO) remain in a compensated state for many years although severe dilation is present. The myocardial capacity to fulfill its energetic demand may delay decompensation. We performed a gene expression profile, a model of chronic VO in rat LV with severe aortic valve regurgitation (AR) for 9 months, and focused on the study of genes associated with myocardial energetics. Methods. LV gene expression profile was performed in rats after 9 months of AR and compared to sham-operated controls. LV glucose and fatty acid (FA) uptake was also evaluated in vivo by positron emission tomography in 8-week AR rats treated or not with fenofibrate, an activator of FA oxidation (FAO). Results. Many LV genes associated with mitochondrial function and metabolism were downregulated in AR rats. FA β-oxidation capacity was significantly impaired as early as two weeks after AR. Treatment with fenofibrate, a PPARα agonist, normalized both FA and glucose uptake while reducing LV dilation caused by AR. Conclusion. Myocardial energy substrate preference is affected early in the evolution of LV-VO cardiomyopathy. Maintaining a relatively normal FA utilization in the myocardium could translate into less glucose uptake and possibly lesser LV remodeling.|
|Document Type:||Article de recherche|
|Issue Date:||25 October 2015|
|Open Access Date:||13 November 2017|
|This document was published in:||BioMed Research International, Vol. 2015, (2015)|
|Collection:||Articles publiés dans des revues avec comité de lecture|
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