One-pot photochemical ring-opening/cleavage approach for the synthesis and decoding of cyclic peptide libraries

Authors: Liang, XinxiaVézina-Dawod, SimonBédard, FrançoisPorte, KarineBiron, Éric
Abstract: A novel dual ring-opening/cleavage strategy to determine the sequence of cyclic peptides from one bead, one compound libraries is described. The approach uses a photolabile residue within the macrocycle and as a linker to allow a simultaneous ring opening and cleavage from the beads upon UV irradiation and provide linearized molecules. Cyclic peptides of five to nine residues were synthesized and the generated linear peptides successfully sequenced by tandem mass spectrometry.
Document Type: Article de recherche
Issue Date: 25 February 2016
Open Access Date: 26 October 2017
Document version: AM
This document was published in: Organic letters, Vol. 18 (5), 1174-1177 (2016)
American Chemical Society
Alternative version: 10.1021/acs.orglett.6b00296
Collection:Articles publiés dans des revues avec comité de lecture

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