Long-term adiposity changes are related to a glucocorticoid receptor polymorphism in young females

DC FieldValueLanguage
dc.contributor.authorTremblay, Angelo-
dc.contributor.authorBouchard, Luigi-
dc.contributor.authorBouchard, Claude-
dc.contributor.authorDesprés, Jean-Pierre-
dc.contributor.authorDrapeau, Vicky-
dc.contributor.authorPérusse, Louis-
dc.coverage.spatialQuébec (Province)fr
dc.date.accessioned2017-09-18T19:42:31Z-
dc.date.available9999-12-31-
dc.date.issued2003-07-01-
dc.identifier.issn0021-972Xfr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/15417-
dc.description.abstractMale and female preadolescents and adolescents who participated in phase 1 of the Québec Family Study, and who were retested about 12 yr later, were recruited and subdivided on the basis of a genetic variant within the intron 2 of the glucocorticoid receptor (GRL IVS2-BclI). The increase in sc adiposity over the 12-yr follow-up period in the 4.5/2.3 genotype female subgroup was more than twice that observed in the 4.5/4.5 and the 2.3/2.3 genotype subgroups (P < 0.01). The statistical significance of this difference was essentially unchanged after adjusting for changes, over time, in percent dietary energy as fat, alcohol consumption, and participation in vigorous physical activity. In male subjects, the same trend was found, but it did not reach statistical significance. In conclusion, this study suggests that a significant interaction effect exists between variation in the glucocorticoid receptor gene and body fat gain in female subjects experiencing the transition between adolescence and adulthood. Further research will, however, be necessary to characterize the lifestyle factors promoting fat accumulation, over time, among genetically susceptible individuals.fr
dc.languageengfr
dc.publisherOxford Academicfr
dc.subjectObesityfr
dc.subjectPhysical activityfr
dc.subjectPolymorphismfr
dc.subjectDietfr
dc.subjectAdolescentfr
dc.subjectAdultfr
dc.subjectAlcohol drinkingfr
dc.subjectFollow-upfr
dc.subjectGenesfr
dc.subjectGenotypefr
dc.subjectIntronsfr
dc.subjectLife stylefr
dc.subjectGlucocorticoid receptorfr
dc.subjectGeneticsfr
dc.subjectFamily studyfr
dc.subjectBody fatfr
dc.subjectPre-teenfr
dc.titleLong-term adiposity changes are related to a glucocorticoid receptor polymorphism in young femalesfr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationThe Journal of clinical endocrinology and metabolism, Vol. 88 (7), 3141–3145 (2003)fr
dc.audienceProfesseurs (Enseignement supérieur)fr
dc.audienceÉtudiantsfr
dc.audienceDoctorantsfr
dc.audienceNutritionnistesfr
dc.identifier.doi10.1210/jc.2002-021521fr
dc.identifier.pubmed12843156fr
dc.subject.rvmGlucocorticoïdes -- Récepteursfr
dc.subject.rvmPolymorphisme génétiquefr
dc.subject.rvmObésitéfr
dc.subject.rvmGraisse (Physiologie)fr
dc.subject.rvmJeunes femmesfr
dc.subject.rvmAdolescentesfr
rioxxterms.versionVersion of Recordfr
rioxxterms.version_of_recordhttp://dx.doi.org/10.1210/jc.2002-021521fr
rioxxterms.project.funder_nameMedical Research Council Canadafr
rioxxterms.project.funder_nameGeorge A. Bray Chair in Nutritionfr
rioxxterms.project.funder_nameCanada Research Chair in Physical Activity, Nutrition and Energy Balancefr
bul.rights.periodeEmbargoInfinifr
Collection:Articles publiés dans des revues avec comité de lecture

Files in this item:
Description SizeFormat 
Tremblay et al_2003.pdf
130.41 kBAdobe PDF    Request a copy
All documents in CorpusUL are protected by Copyright Act of Canada.