Neuromedin β : a strong candidate gene linking eating behaviors and susceptibility to obesity

Élément Dublin CoreValeurLangue
dc.contributor.authorBouchard, Luigi-
dc.contributor.authorDrapeau, Vicky-
dc.contributor.authorProvencher, Véronique-
dc.contributor.authorLemieux, Simone-
dc.contributor.authorChagnon, Yvon C.-
dc.contributor.authorChagnon, Yvon C.-
dc.contributor.authorRice, Treva-
dc.contributor.authorRao, D. C. (Dabeeru C.)-
dc.contributor.authorVohl, Marie-Claude-
dc.contributor.authorTremblay, Angelo-
dc.contributor.authorBouchard, Claude-
dc.contributor.authorPérusse, Louis-
dc.description.abstractBackground: Obesity is frequently associated with eating disorders, and evidence indicates that both conditions are influenced by genetic factors. However, little is known about the genes influencing eating behaviors. Objective: The objective was to identify genes associated with eating behaviors. Design: Three eating behaviors were assessed in 660 adults from the Québec Family Study with the use of the Three-Factor Eating Questionnaire. A genome-wide scan was conducted with a total of 471 genetic markers spanning the 22 autosomes to identify quantitative trait loci for eating behaviors. Body composition and macronutrient and energy intakes were also measured. Results: Four quantitative trait loci were identified for disinhibition and susceptibility to hunger. Of these, the best evidence of linkage was found between a locus on chromosome 15q24-q25 and disinhibition (P < 0.0058) and susceptibility to hunger (P < 0.0001). After fine-mapping, the peak linkage was found between markers D15S206 and D15S201 surrounding the neuromedin β (NMB) gene. A missense mutation (p.P73T) located within the NMB gene showed significant associations with eating behaviors and obesity phenotypes. The T73T homozygotes were 2 times as likely to exhibit high levels of disinhibition (odds ratio: 1.8; 95% CI: 1.07, 2.89; P = 0.03) and susceptibility to hunger (odds ratio: 1.9; 95% CI: 1.15, 3.06; P = 0.01) as were the P73 allele carriers. Six-year follow-up data showed that the amount of body fat gain over time in T73T subjects was >2 times that than in P73P homozygotes (3.6 compared with 1.5 kg; P < 0.05fr
dc.publisherJournal of Clinical Nutritionfr
dc.subjectCognitive dietary restraintfr
dc.subjectSusceptibility to hungerfr
dc.subjectBehavioral geneticsfr
dc.subjectThree-Factor Eating Questionnairefr
dc.subjectQuantitative trait locusfr
dc.titleNeuromedin β : a strong candidate gene linking eating behaviors and susceptibility to obesityfr
dc.title.alternativeNeuromedin beta : a strong candidate gene linking eating behaviors and susceptibility to obesityfr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationThe American journal of clinical nutrition, Vol. 80 (6), 1478-1486 (2004)fr
dc.audienceProfesseurs (Enseignement supérieur)fr
dc.subject.rvmNeurokinine Bfr
dc.subject.rvmGénétique du comportementfr
dc.subject.rvmHabitudes alimentaires -- Aspect génétiquefr
rioxxterms.versionVersion of Recordfr
Collection :Articles publiés dans des revues avec comité de lecture

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