Neuromedin β : a strong candidate gene linking eating behaviors and susceptibility to obesity

Authors: Bouchard, LuigiDrapeau, VickyProvencher, VéroniqueLemieux, SimoneChagnon, Yvon C.Chagnon, Yvon C.; Rice, Treva; Rao, D. C. (Dabeeru C.); Vohl, Marie-ClaudeTremblay, AngeloBouchard, ClaudePérusse, Louis
Abstract: Background: Obesity is frequently associated with eating disorders, and evidence indicates that both conditions are influenced by genetic factors. However, little is known about the genes influencing eating behaviors. Objective: The objective was to identify genes associated with eating behaviors. Design: Three eating behaviors were assessed in 660 adults from the Québec Family Study with the use of the Three-Factor Eating Questionnaire. A genome-wide scan was conducted with a total of 471 genetic markers spanning the 22 autosomes to identify quantitative trait loci for eating behaviors. Body composition and macronutrient and energy intakes were also measured. Results: Four quantitative trait loci were identified for disinhibition and susceptibility to hunger. Of these, the best evidence of linkage was found between a locus on chromosome 15q24-q25 and disinhibition (P < 0.0058) and susceptibility to hunger (P < 0.0001). After fine-mapping, the peak linkage was found between markers D15S206 and D15S201 surrounding the neuromedin β (NMB) gene. A missense mutation (p.P73T) located within the NMB gene showed significant associations with eating behaviors and obesity phenotypes. The T73T homozygotes were 2 times as likely to exhibit high levels of disinhibition (odds ratio: 1.8; 95% CI: 1.07, 2.89; P = 0.03) and susceptibility to hunger (odds ratio: 1.9; 95% CI: 1.15, 3.06; P = 0.01) as were the P73 allele carriers. Six-year follow-up data showed that the amount of body fat gain over time in T73T subjects was >2 times that than in P73P homozygotes (3.6 compared with 1.5 kg; P < 0.05
Document Type: Article de recherche
Issue Date: 1 January 2004
Open Access Date: Restricted access
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/15411
This document was published in: The American journal of clinical nutrition, Vol. 80 (6), 1478-1486 (2004)
http://ajcn.nutrition.org/content/80/6/1478.full
Journal of Clinical Nutrition
Alternative version: 15585758
Collection:Articles publiés dans des revues avec comité de lecture

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