Metabolic and inflammatory profile in obese patients with chronic obstructive pulmonary disease

DC FieldValueLanguage
dc.contributor.authorPoulain, Magali-
dc.contributor.authorDoucet, Mariève-
dc.contributor.authorDrapeau, Vicky-
dc.contributor.authorFournier, Guy-
dc.contributor.authorTremblay, Angelo-
dc.contributor.authorPoirier, Paul-
dc.contributor.authorMaltais, François-
dc.date.accessioned2017-09-14T20:48:23Z-
dc.date.available2017-09-14T20:48:23Z-
dc.date.issued2008-02-01-
dc.identifier.issn1479-9723fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/15392-
dc.description.abstractBackground: Overweight and obesity have been associated with better survival in patients with chronic obstructive pulmonary disease (COPD). On the other hand, excess body weight is associated with abnormal metabolic and inflammatory profiles that define the metabolic syndrome and predispose to cardiovascular diseases. This study was undertaken to evaluate the impact of overweight and obesity on the prevalence of the metabolic syndrome and on the metabolic and inflammatory profiles in patients with COPD. Methods: Twenty-eight male patients with COPD were divided into an overweight/obese group [n 16, body mass index (BMI) 33.5 4.2 kg/m2] and normal weight group (n 12, BMI 21.1 2.6 kg/m2). Anthropometry, pulmonary function and body composition were assessed. The metabolic syndrome was diagnosed according to waist circumference, circulating levels of triglyceride and high-density lipoprotein cholesterol levels, fasting glycemia and blood pressure. C-reactive protein, tumor necrosis factor- (TNF-), interleukin-6 (IL-6), leptin and adiponectin plasma levels were measured. Results: Airflow obstruction was less severe in overweight/obese compared with normal weight patients (forced expiratory volume1: 51 19% versus 31 12% predicted, respectively, P 0.01). The metabolic syndrome was diagnosed in 50% of overweight/obese patients and in none of the normal weight patients. TNF-, IL-6 and leptin were significantly higher in overweight/obese patients whereas the adiponectin levels were reduced in the presence of excess weight. Conclusions: The metabolic syndrome was frequent in overweight/obese patients with COPD. Obesity in COPD was associated with a spectrum of metabolic and inflammatory abnormalities.fr
dc.languageengfr
dc.publisherArnoldfr
dc.subjectCardiovascular diseasesfr
dc.subjectCOPDfr
dc.subjectDiabetesfr
dc.subjectInflammationfr
dc.subjectMetabolic syndromefr
dc.subjectObesityfr
dc.titleMetabolic and inflammatory profile in obese patients with chronic obstructive pulmonary diseasefr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationChronic Respiratory Diseases, Vol. 5 (1), 35–41 (2008)fr
dc.audienceProfesseurs (Enseignement supérieur)fr
dc.audienceÉtudiantsfr
dc.audienceDoctorantsfr
dc.identifier.doi10.1177/1479972307087205fr
dc.identifier.pubmed18303100fr
dc.subject.rvmSyndrome métaboliquefr
dc.subject.rvmAppareil cardiovasculaire -- Maladiesfr
dc.subject.rvmPoumons -- Maladies obstructivesfr
dc.subject.rvmObésitéfr
rioxxterms.versionVersion of Recordfr
rioxxterms.version_of_recordhttps://doi.org/10.1177/1479972307087205fr
rioxxterms.project.funder_nameGroupe de Recherche en santé respiratoire de l’Université Lavalfr
bul.rights.periodeEmbargo0 moisfr
Collection:Articles publiés dans des revues avec comité de lecture

Files in this item:
Description SizeFormat 
Poulain_2008.pdf229.48 kBAdobe PDFThumbnail
View/Open
All documents in CorpusUL are protected by Copyright Act of Canada.