Metabolic and inflammatory profile in obese patients with chronic obstructive pulmonary disease

Authors: Poulain, MagaliDoucet, MarièveDrapeau, VickyFournier, GuyTremblay, AngeloPoirier, PaulMaltais, François
Abstract: Background: Overweight and obesity have been associated with better survival in patients with chronic obstructive pulmonary disease (COPD). On the other hand, excess body weight is associated with abnormal metabolic and inflammatory profiles that define the metabolic syndrome and predispose to cardiovascular diseases. This study was undertaken to evaluate the impact of overweight and obesity on the prevalence of the metabolic syndrome and on the metabolic and inflammatory profiles in patients with COPD. Methods: Twenty-eight male patients with COPD were divided into an overweight/obese group [n 16, body mass index (BMI) 33.5 4.2 kg/m2] and normal weight group (n 12, BMI 21.1 2.6 kg/m2). Anthropometry, pulmonary function and body composition were assessed. The metabolic syndrome was diagnosed according to waist circumference, circulating levels of triglyceride and high-density lipoprotein cholesterol levels, fasting glycemia and blood pressure. C-reactive protein, tumor necrosis factor- (TNF-), interleukin-6 (IL-6), leptin and adiponectin plasma levels were measured. Results: Airflow obstruction was less severe in overweight/obese compared with normal weight patients (forced expiratory volume1: 51 19% versus 31 12% predicted, respectively, P 0.01). The metabolic syndrome was diagnosed in 50% of overweight/obese patients and in none of the normal weight patients. TNF-, IL-6 and leptin were significantly higher in overweight/obese patients whereas the adiponectin levels were reduced in the presence of excess weight. Conclusions: The metabolic syndrome was frequent in overweight/obese patients with COPD. Obesity in COPD was associated with a spectrum of metabolic and inflammatory abnormalities.
Document Type: Article de recherche
Issue Date: 1 February 2008
Open Access Date: 14 September 2017
Document version: VoR
This document was published in: Chronic Respiratory Diseases, Vol. 5 (1), 35–41 (2008)
Alternative version: 10.1177/1479972307087205
Collection:Articles publiés dans des revues avec comité de lecture

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