GAD2 gene sequence variations are associated with eating behaviors and weight gain in women from the Quebec family study

Auteur(s): Choquette, AnneLemieux, SimoneTremblay, AngeloDrapeau, VickyBouchard, ClaudeVohl, Marie-ClaudePérusse, Louis
Résumé: The glutamate decarboxylase 2 (GAD2) gene encodes for the glutamic acid decarboxylase enzyme (GAD65), which is implicated in the formation of the γ-aminobutyric acid (GABA), a neurotransmitter involved in the regulation of food intake. The objective of the present study was to test for association between GAD2 singlenucleotide polymorphisms (SNPs) and eating behaviors, dietary intake and obesity in subjects (n= 873) from the Quebec Family Study (QFS). Energy and macronutrient intakes were measured using a 3-day dietary record and eating behaviors were assessed using the Three-Factor Eating Questionnaire (TFEQ). Six SNPs capturing about 90% of GAD2 gene variability were genotyped and tested for association with age- and BMI- adjusted phenotypes. No evidence of association was found in men. In women, a SNP (rs992990; c.61450 C>A) was associated with disinhibition (p= 0.028), emotional susceptibility to disinhibition (p= 0.0005) and susceptibility to hunger (p= 0.028). Another SNP (rs7908975; c.8473A>C) was associated with carbohydrate (p= 0.021) and lipid (p= 0.021) intakes, disinhibition (p= 0.011) and two of its subscales (emotional and situational susceptibility) as well as with avoidance of fattening foods (p= 0.036). Six-year weight gain was two times higher in women carrying the variants associated with eating behaviors: 4.2 kg (vs 2.1 kg in non-carriers) in A-allele carriers of c.61450 C>A (p= 0.038) and 4.9 kg (vs 2.5 kg in noncarriers) in C-allele carriers of c. 8473 A>C (p= 0.013). The results suggest a role for the GAD2 gene in determining food intake, eating behaviors and weight gain over time in women.
Type de document: Article de recherche
Date de publication: 15 août 2009
Date de la mise en libre accès: Accès restreint
Version du document: VoR
Lien permanent: http://hdl.handle.net/20.500.11794/15390
Ce document a été publié dans: Physiology and Behaviours, Vol. 98 (4), 505–510 (2009)
https://doi.org/10.1016/j.physbeh.2009.08.004
Pergamon Press
Autre version disponible: 10.1016/j.physbeh.2009.08.004
19686769
Collection :Articles publiés dans des revues avec comité de lecture

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