Normalized left ventricular workload using phase-contrast magnetic resonance imaging in patients with aortic stenosis.

Authors: Garcia, Julio; Keshavarz-Motamed, Zahra; Capoulade, Romain; Le Ven, Florent; Kadem, LyesLarose, ÉricPibarot, Philippe
Abstract: Aortic stenosis (AS) severity contributes to the left ventricle (LV) deterioration due to the aortic valve narrowing and the alteration of systemic hemodynamic load. This load increment may also increase the LV stroke work (SW) which represent the required energy to deliver the blood at ejection. In this study, SW was derived from in-vivo cardiovascular magnetic resonance (CMR) velocity measurements (n=57) using a lumped-parametric model. Furthermore, normalized SW (N-SW) was evaluated as AS severity parameter. SW differentiated from normal flow (>35 mL/m2 ) and low flow (<35 mL/m2 ) states (p<0.05). N-SW showed a good association with valve effective orifice area (EOA, r=-0.5, p<0.001) and valvuloarterial impedance (ZVA, r=0.65, p<0.001). A severity threshold for N-SW (1.5 cJ/mL) was found using an EOA=1 cm2 as AS severity marker. CMR-derived SW and N-SW may be useful to the assessment and grading of AS patients.
Document Type: Article dans une conférence
Issue Date: 31 August 2014
Open Access Date: Restricted access
Document version: VoR
This document was published in: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 6430 - 6433 (2014)
Institute of Electrical and Electronics Engineers
Alternative version: 10.1109/EMBC.2014.6945100
Collection:Chapitres de livre

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