Sleep oscillations in the thalamocortical system induce long-term neuronal plasticity

DC FieldValueLanguage
dc.contributor.authorChauvette, Sylvain-
dc.contributor.authorSeigneur, Josée-
dc.contributor.authorTimofeev, Igor-
dc.date.accessioned2017-05-05T19:15:50Z-
dc.date.available10000-01-01-
dc.date.issued2012-09-19-
dc.identifier.issn0896-6273fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/13926-
dc.description.abstractLong-term plasticity contributes to memory formation and sleep plays a critical role in memory consolidation. However, it is unclear whether sleep slow oscillation by itself induces long-term plasticity that contributes to memory retention. Using in vivo prethalamic electrical stimulation at 1 Hz, which itself does not induce immediate potentiation of evoked responses, we investigated how the cortical evoked response was modulated by different states of vigilance. We found that somatosensory evoked potentials during wake were enhanced after a slow-wave sleep episode (with or without stimulation during sleep) as compared to a previous wake episode. In vitro, we determined that this enhancement has a postsynaptic mechanism that is calcium dependent, requires hyperpolarization periods (slow waves), and requires a coactivation of both AMPA and NMDA receptors. Our results suggest that long-term potentiation occurs during slow-wave sleep, supporting its contribution to memory.fr
dc.languageengfr
dc.publisherElsevierfr
dc.titleSleep oscillations in the thalamocortical system induce long-term neuronal plasticityfr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationNeuron, Vol. 75 (6), 1105–1113 (2012)fr
dc.audienceProfesseurs (Enseignement supérieur)fr
dc.audienceÉtudiantsfr
dc.audienceDoctorantsfr
dc.audienceNeurologuesfr
dc.identifier.doi10.1016/j.neuron.2012.08.034fr
dc.identifier.pubmed22998877fr
dc.subject.rvmPlasticité neuronalefr
dc.subject.rvmMémoirefr
dc.subject.rvmSommeil -- Aspect physiologiquefr
rioxxterms.versionVersion of Recordfr
rioxxterms.version_of_recordhttps://doi.org/10.1016/j.neuron.2012.08.034fr
rioxxterms.project.funder_nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder_nameNatural Sciences and Engineering Research Council of Canadafr
rioxxterms.project.funder_nameNational Institute of Neurological Disorders and Strokefr
rioxxterms.project.funder_nameFonds de Recherche du Québec - Santéfr
bul.rights.periodeEmbargoInfinifr
dc.audience.peerreviewOuifr
Collection:Articles publiés dans des revues avec comité de lecture

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