Sleep oscillations in the thalamocortical system induce long-term neuronal plasticity

Authors: Chauvette, SylvainSeigneur, JoséeTimofeev, Igor
Abstract: Long-term plasticity contributes to memory formation and sleep plays a critical role in memory consolidation. However, it is unclear whether sleep slow oscillation by itself induces long-term plasticity that contributes to memory retention. Using in vivo prethalamic electrical stimulation at 1 Hz, which itself does not induce immediate potentiation of evoked responses, we investigated how the cortical evoked response was modulated by different states of vigilance. We found that somatosensory evoked potentials during wake were enhanced after a slow-wave sleep episode (with or without stimulation during sleep) as compared to a previous wake episode. In vitro, we determined that this enhancement has a postsynaptic mechanism that is calcium dependent, requires hyperpolarization periods (slow waves), and requires a coactivation of both AMPA and NMDA receptors. Our results suggest that long-term potentiation occurs during slow-wave sleep, supporting its contribution to memory.
Document Type: Article de recherche
Issue Date: 19 September 2012
Open Access Date: Restricted access
Document version: VoR
This document was published in: Neuron, Vol. 75 (6), 1105–1113 (2012)
Alternative version: 10.1016/j.neuron.2012.08.034
Collection:Articles publiés dans des revues avec comité de lecture

Files in this item:
Description SizeFormat 
1.29 MBAdobe PDF    Request a copy
255.03 kBAdobe PDF    Request a copy
All documents in CorpusUL are protected by Copyright Act of Canada.