Sex differences in the impact of the Mediterranean diet on LDL particle size distribution and oxidation

DC FieldValueLanguage
dc.contributor.authorBédard, Alexandra-
dc.contributor.authorCorneau, Louise-
dc.contributor.authorLamarche, Benoît-
dc.contributor.authorDodin-Dewailly, Sylvie-
dc.contributor.authorLemieux, Simone-
dc.coverage.spatialMéditerranée, Région de lafr_CA
dc.description.abstractSex differences have been previously highlighted in the cardioprotective effects of the Mediterranean diet (MedDiet). The objective of this study was to investigate whether sex differences also exist with regard to LDL particle size distribution and oxidation. Participants were 37 men and 32 premenopausal women (24–53 years) with slightly elevated LDL-C concentrations (3.4–4.9 mmol/L) or total cholesterol/HDL-C =5.0. Variables were measured before and after a four-week isoenergetic MedDiet. Sex differences were found in response to the MedDiet for the proportion of medium LDL (255–260 Å) (p for sex-by-time interaction = 0.01) and small, dense LDL (sdLDL; <255 Å) (trend; p for sex-by-time interaction = 0.06), men experiencing an increase in the proportion of medium LDL with a concomitant reduction in the proportion of sdLDL, while an opposite trend was observed in women. A sex difference was also noted for estimated cholesterol concentrations among sdLDL (p for sex-by-time interaction = 0.03), with only men experiencing a reduction in response to the MedDiet. The MedDiet marginally reduced oxidized LDL (oxLDL) concentrations (p = 0.07), with no sex difference. Results suggest that short-termconsumption of the MedDiet leads to a favorable redistribution of LDL subclasses from smaller to larger LDL only in men. These results highlight the importance of considering sex issues in cardiovascular benefits of the MedDietfr_CA
dc.subjectMediterranean dietfr_CA
dc.subjectLDL sizefr_CA
dc.subjectoxidized LDLfr_CA
dc.subjectRégime méditerranéenfr_CA
dc.titleSex differences in the impact of the Mediterranean diet on LDL particle size distribution and oxidationfr_CA
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr_CA
dcterms.bibliographicCitationNutrients, Vol. 7 (5), 3705-3723 (2015)fr_CA
dc.audienceProfesseurs (Enseignement supérieur)fr_CA
dc.subject.rvmDifférences entre sexesfr_CA
dc.subject.rvmLipoprotéines de basse densitéfr_CA
rioxxterms.versionVersion of Recordfr_CA
rioxxterms.projectMOP 84568fr_CA
rioxxterms.project.funder_nameCanadian Institutes of Health Researchfr_CA
bul.rights.periodeEmbargo0 moisfr_CA
Collection:Articles publiés dans des revues avec comité de lecture

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