Immunologic mechanisms in the adaptation of swine farm workers to their work environment

DC FieldValueLanguage
dc.contributor.authorBønløkke, Jakob Hjort-
dc.contributor.authorCormier, Yvon-
dc.contributor.authorVeillette, Marc-
dc.contributor.authorRadu, Arnold-
dc.contributor.authorMériaux, Anne-
dc.contributor.authorDuchaine, Caroline-
dc.description.abstractSwine building exposure causes inflammatory reactions that appear to be attenuated with prolonged periods of contact. The mechanisms behind this adaptation to a dusty and endotoxin-rich environment are poorly understood. Our aim was to compare levels of selected inflammatory mediators in swine farm workers at times with differences in exposure. Participants had blood sampling done before and after each of three work shifts—two in winter and one in summer. Before one of the winter visits they had avoided pulmonary exposure to the swine buildings by wearing respiratory protection for 4 d. The other visits were done after non-protected periods of work. Protein and mRNA concentrations were measured in blood. Mixed models were used for the statistics. During summer higher concentrations of mRNA to IL-8, lymphocyte function-associated antigen 1 and bactericidal/permeability-increasing protein (BPI) were observed. BPI mRNA increased only over the work shift after the unprotected winter period (P¿=¿0.039). BPI decreased from elevated levels across the shift after use of respiratory protection (P¿=¿0.003), but was unchanged during the other two visits. The findings suggest possible roles for these proteins in adaptation to the swine building environment after repeated exposures.fr_CA
dc.publisherInternational Endotoxin & Innate Immunity Societyfr_CA
dc.subjectBioaerosol exposurefr_CA
dc.subjectInflammatory mediatorsfr_CA
dc.subjectmRNA expressionfr_CA
dc.subjectSwine confinement housesfr_CA
dc.subjectWork environmentfr_CA
dc.titleImmunologic mechanisms in the adaptation of swine farm workers to their work environmentfr_CA
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche-
dcterms.bibliographicCitationInnate Immunity, Vol. 19 (4), 403–410 (2013)fr_CA
dc.audienceProfesseurs (Enseignement supérieur)fr_CA
dc.subject.rvmTravailleurs de l'élevage -- Santé et hygiènefr_CA
dc.subject.rvmAir -- Microbiologiefr_CA
dc.subject.rvmRéaction immunitairefr_CA
dc.subject.rvmPorcheries -- Aspect sanitairefr_CA
dc.subject.rvmARN messagerfr_CA
dc.subject.rvmBâtiments de confinement (Agriculture) -- Aspect sanitairefr_CA
dc.subject.rvmInflammation (Pathologie) -- Médiateursfr_CA
rioxxterms.versionVersion of Recordfr_CA
Collection:Articles publiés dans des revues avec comité de lecture

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