The dementia-associated APOE e4 allele is not associated with rapid eye movement sleep behavior disorder

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dc.contributor.authorGan-Or, Ziv-
dc.contributor.authorMontplaisir, Jacques Y.-
dc.contributor.authorRoss, Jay P.-
dc.contributor.authorPoirier, Judes-
dc.contributor.authorWarby, Simon C.-
dc.contributor.authorArnulf, Isabelle-
dc.contributor.authorStrong, Stephanie-
dc.contributor.authorDauvilliers, Yves-
dc.contributor.authorLeblond, Claire S.-
dc.contributor.authorHu, Michele T.M.-
dc.contributor.authorHögl, Birgit-
dc.contributor.authorStefani, Ambra-
dc.contributor.authorMonaca, Christelle-
dc.contributor.authorCochen De Cock, Valérie-
dc.contributor.authorBoivin, Michel-
dc.contributor.authorFerini-Strambi, Luigi-
dc.contributor.authorPlazzi, Giuseppe-
dc.contributor.authorAntelmi, Elena-
dc.contributor.authorYoung, Peter-
dc.contributor.authorHeidbreder, Anna-
dc.contributor.authorBarber, Thomas R.-
dc.contributor.authorEvetts, Samuel G.-
dc.contributor.authorRolinski, Michal-
dc.contributor.authorDion, Patrick A.-
dc.contributor.authorDesautels, Alex-
dc.contributor.authorGagnon, Jean-François-
dc.contributor.authorDupré, Nicolas-
dc.contributor.authorPostuma, Ronald B.-
dc.contributor.authorRouleau, Guy A.-
dc.description.abstractThe present study aimed to examine whether the APOE e4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE e4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88–1.40, p = 0.41). APOE e4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE e4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.fr_CA
dc.subjectREM sleep behavior disorderfr_CA
dc.subjectParkinson's diseasefr_CA
dc.subjectDementia with Lewy bodiesfr_CA
dc.titleThe dementia-associated APOE e4 allele is not associated with rapid eye movement sleep behavior disorderfr_CA
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche-
dcterms.bibliographicCitationNeurobiology of Aging, (2016)fr_CA
dc.audienceProfesseurs (Enseignement supérieur)fr_CA
dc.subject.rvmApolipoprotéine Efr_CA
dc.subject.rvmMaladie des corps de Lewyfr_CA
dc.subject.rvmSommeil paradoxalfr_CA
dc.subject.rvmMaladie de Parkinsonfr_CA
rioxxterms.versionAccepted Manuscriptfr_CA
bul.rights.periodeEmbargo12 moisfr_CA
Collection:Articles publiés dans des revues avec comité de lecture

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