The dementia-associated APOE e4 allele is not associated with rapid eye movement sleep behavior disorder

Authors: Gan-Or, Ziv; Montplaisir, Jacques Y.; Ross, Jay P.; Poirier, Judes; Warby, Simon C.; Arnulf, Isabelle; Strong, Stephanie; Dauvilliers, Yves; Leblond, Claire S.; Hu, Michele T.M.; Högl, Birgit; Stefani, Ambra; Monaca, Christelle; Cochen De Cock, Valérie; Boivin, Michel; Ferini-Strambi, Luigi; Plazzi, Giuseppe; Antelmi, Elena; Young, Peter; Heidbreder, Anna; Barber, Thomas R.; Evetts, Samuel G.; Rolinski, Michal; Dion, Patrick A.; Desautels, Alex; Gagnon, Jean-François; Dupré, Nicolas; Postuma, Ronald B.; Rouleau, Guy A.
Abstract: The present study aimed to examine whether the APOE e4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE e4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88–1.40, p = 0.41). APOE e4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE e4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.
Document Type: Article de recherche
Issue Date: 13 October 2016
Open Access Date: 13 October 2017
Document version: AM
This document was published in: Neurobiology of Aging, (2016)
Alternative version: 10.1016/j.neurobiolaging.2016.10.002
Collection:Articles publiés dans des revues avec comité de lecture

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