Recent progress in the development of protein-protein interaction inhibitors targeting androgen receptor-coactivator binding in prostate cancer

Auteur(s): Biron, ÉricBédard, François
Résumé: The androgen receptor (AR) is a key regulator for the growth, differentiation and survival of prostate cancer cells. Identified as a primary target for the treatment of prostate cancer, many therapeutic strategies have been developed to attenuate AR signaling in prostate cancer cells. While frontline androgen-deprivation therapies targeting either the production or action of androgens usually yield favourable responses in prostate cancer patients, a significant number acquire treatment resistance. Known as the castration-resistant prostate cancer (CRPC), the treatment options are limited for this advanced stage. It has been shown that AR signaling is restored in CRPC due to many aberrant mechanisms such as AR mutations, amplification or expression of constitutively active splice-variants. Coregulator recruitment is a crucial regulatory step in AR signaling and the direct blockade of coactivator binding to AR offers the opportunity to develop therapeutic agents that would remain effective in prostate cancer cells resistant to conventional endocrine therapies. Structural analyses of the AR have identified key surfaces involved in protein-protein interaction with coregulators that have been recently used to design and develop promising AR-coactivator binding inhibitors. In this review we will discuss the design and development of small-molecule inhibitors targeting the AR-coactivator interactions for the treatment of prostate cancer.
Type de document: Article de recherche
Date de publication: 18 juillet 2015
Date de la mise en libre accès: 30 septembre 2016
Version du document: AM
Lien permanent: http://hdl.handle.net/20.500.11794/10708
Ce document a été publié dans: The Journal of steroid biochemistry and molecular biology, Vol. 161, 36–44 (2016)
https://doi.org/10.1016/j.jsbmb.2015.07.006
Pergamon Press
Autre version disponible: 10.1016/j.jsbmb.2015.07.006
26196120
Collection :Articles publiés dans des revues avec comité de lecture

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