CorpusUL
CorpusUL, Université Laval's Institutional repository preserves and enables easy and open access to scientific literature.
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Alipogene tiparvovec (Glybera) is a gene therapy product approved in Europe under the “exceptional circumstances” pathway as a treatment for lipoprotein lipase deficiency (LPLD), a rare genetic disease resulting in chylomicronemia and a concomitantly increased risk of acute and recurrent pancreatitis, with potentially lethal outcome. This retrospective study analyzed the frequency and severity of pancreatitis in 19 patients with LPLD up to 6 years after a single treatment with alipogene tipar...
This article proposes an approach to improve the deployment of ground penetrating radar (GPR) in the field to detected and locate urban infrastructures. It consists of exploiting geographic data layers, database management systems, and a WebGIS, allowing users to handle GPR data within a georeferenced environment is developed based on a platform called GVX, providing users with four features, being (1) map integration, (2) geo-annotations and points of interest interaction, (3) radargram geor...
One-year results are reported of the first lipoprotein lipase deficiency (LPLD) patient treated with alipogene tiparvovec, which is indicated for the treatment of patients with genetically confirmed LPLD suffering from acute and recurrent pancreatitis attacks (PAs) despite dietary restrictions and expressing >5% of lipoprotein lipase (LPL) mass compared to a healthy control. During clinical development, alipogene tiparvovec has shown improvement of chylomicron metabolism and reduction of panc...
Alipogene tiparvovec (AAV1-LPLS447X) gene therapy is developed to prevent complications and decrease the clinical morbidity of lipoprotein lipase deficiency (LPLD). LPLD is an autosomal recessive disease associated with severe hypertriglyceridemia (hyperTG), severe chylomicronaemia, and low HDL. Acute pancreatitis, the most frequent serious clinical LPLD complication, is a complex and heterogeneous inflammatory condition having many causes including hyperTG and chylomicronaemia. In many patie...