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Publication :
Autotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery disease

bul.description.provenanceeb bde spbfr
bul.rights.dateAccepPubl2020-05-30fr
bul.rights.periodeEmbargoforeverfr
bul.rights.raisonEmbargoInfiniL’éditeur de Journal of internal medicine n’autorise pas la diffusion en libre accès dans un dépôt institutionnel.fr
bul.rights.typeDatedatePublicationfr
dc.contributor.authorSimard, Sébastien
dc.contributor.authorBouchareb, Rihab
dc.contributor.authorArsenault, Benoit
dc.contributor.authorBoulanger, Marie-Chloé
dc.contributor.authorBossé, Yohan
dc.contributor.authorMahmut, Ablajan
dc.contributor.authorWitztum, Joseph L.
dc.contributor.authorPibarot, Philippe
dc.contributor.authorClavel, Marie-Annick
dc.contributor.authorNsaibia, Mohamed Jalloul
dc.contributor.authorMathieu, Patrick
dc.contributor.authorTsimikas, Sotirios
dc.date.accessioned2020-06-29T11:56:33Z
dc.date.available9999-12-31
dc.date.issued2020-05-30
dc.description.abstractBackground Studies have shown that lipoprotein(a) [Lp(a)], an important carrier of oxidized phospholipids, is causally related to calcific aortic valve stenosis (CAVS). Recently, we found that Lp(a) mediates the development of CAVS through autotaxin (ATX). Objective To determine the predictive value of circulating ATX mass and activity for CAVS. Methods We performed a case-control study in 300 patients with coronary artery disease (CAD). Patients with CAVS plus CAD (cases, n = 150) were age- and gender-matched (1 : 1) to patients with CAD without aortic valve disease (controls, n = 150). ATX mass and enzymatic activity and levels of Lp(a) and oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) were determined in fasting plasma samples. Results Compared to patients with CAD alone, ATX mass (P < 0.0001), ATX activity (P = 0.05), Lp(a) (P = 0.003) and OxPL-apoB (P < 0.0001) levels were elevated in those with CAVS. After adjustment, we found that ATX mass (OR 1.06, 95% CI 1.03–1.10 per 10 ng mL−1, P = 0.001) and ATX activity (OR 1.57, 95% CI 1.14–2.17 per 10 RFU min−1, P = 0.005) were independently associated with CAVS. ATX activity interacted with Lp(a) (P = 0.004) and OxPL-apoB (P = 0.001) on CAVS risk. After adjustment, compared to patients with low ATX activity (dichotomized at the median value) and low Lp(a) (<50 mg dL−1) or OxPL-apoB (<2.02 nmol L−1, median) levels (referent), patients with both higher ATX activity (≥84 RFU min−1) and Lp(a) (≥50 mg dL−1) (OR 3.46, 95% CI 1.40–8.58, P = 0.007) or OxPL-apoB (≥2.02 nmol L−1, median) (OR 5.48, 95% CI 2.45–12.27, P < 0.0001) had an elevated risk of CAVS. Conclusion Autotaxin is a novel and independent predictor of CAVS in patients with CAD.fr
dc.identifier.doi10.1111/joim.12519fr
dc.identifier.issn0954-6820fr
dc.identifier.pubmed27237700fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/39597
dc.languageengfr
dc.publisherBlackwell Scientific Publicationfr
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subjectAutotaxinfr
dc.subjectCalcific aortic valve diseasefr
dc.subjectCalcific aortic valve stenosisfr
dc.subjectLipoprotein(a)fr
dc.subjectOxidized phospholipidsfr
dc.subject.rvmLipoprotéine Afr
dc.subject.rvmAorte -- Rétrécissementfr
dc.subject.rvmValve aortique -- Calcificationfr
dc.subject.rvmPhospholipidesfr
dc.subject.rvmArtères coronaires -- Maladiesfr
dc.titleAutotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery diseasefr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationJournal of internal medicine, Vol. 280 (5), 509–517 (2016)fr
dspace.accessstatus.time2024-03-16 18:17:54
dspace.entity.typePublication
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rioxxterms.project.funder-nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder-nameHeart and Stroke Foundation of Canadafr
rioxxterms.project.funder-nameQuebec Heart and Lung University Institute Foundationfr
rioxxterms.versionVersion of Record (VoR)fr
rioxxterms.version-of-recordhttps://doi.org/10.1111/joim.12519fr

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