Publication :
Applications of CRISPR-Cas in its natural habitat

Notice brève
bul.description.provenanceeb spbfr
bul.rights.dateAccepPubl2016-06-07fr
bul.rights.periodeEmbargoforeverfr
bul.rights.raisonEmbargoInfiniPour que le document soit diffusé en libre accès, en accord avec le délai prescrit par l’éditeur de CURRENT OPINION IN CHEMICAL BIOLOGY, il faudrait déposer la version acceptée pour publication, incluant toutes les modifications demandées, mais sans la mise en page de la revue. Pour ce faire, effectuez une demande de modification à l’aide de la liste des dépôts diffusés à partir du tableau de suivi.fr
bul.rights.typeDatedatePublicationfr
dc.contributor.authorLemay, Marie-Laurence
dc.contributor.authorMoineau, Sylvain
dc.contributor.authorHynes, Alexander
dc.date.accessioned2020-04-15T17:55:23Z
dc.date.available9999-12-31
dc.date.issued2016-06-07
dc.description.abstractKey components of CRISPR-Cas systems have been adapted into a powerful genome-editing tool that has caught the headlines and the attention of the public. Canonically, a customized RNA serves to guide an endonuclease (e.g. Cas9) to its DNA target, resulting in precise genomic lesions that can be repaired in a personalized fashion by cellular machinery. Here, we turn to the microbes that are the source of this system to explore many of its other notable applications. These include mining the CRISPR 'memory' arrays for functional genomic data, generation of customized virus-resistant or plasmid-refractory bacterial cells, editing of previously intractable viral genomes, and exploiting the unique properties of a catalytically inactive Cas9, dCas9, to serve as a highly customizable anti-nucleic acid 'antibody'.fr
dc.identifier.doi10.1016/j.cbpa.2016.05.021fr
dc.identifier.issn1367-5931fr
dc.identifier.pubmed27280696fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/38759
dc.languageengfr
dc.publisherElsevierfr
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subject.rvmSystèmes CRISPR-Casfr
dc.titleApplications of CRISPR-Cas in its natural habitatfr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationCurrent Opinion in Chemical Biology, Vol. 34, 30–36 (2016)fr
dspace.accessstatus.time2023-05-26 18:00:40
dspace.entity.typePublication
relation.isAuthorOfPublication579b25df-c113-4616-8b8c-44bb3c0a9d12
relation.isAuthorOfPublication599b62d2-4b51-4b07-9539-3cef15723b3f
relation.isAuthorOfPublication5e457313-89bc-4fb2-853b-25175ea6fe35
relation.isAuthorOfPublication.latestForDiscovery579b25df-c113-4616-8b8c-44bb3c0a9d12
relation.isResourceTypeOfPublication4c433ef5-3937-4530-8252-cca17d715747
relation.isResourceTypeOfPublication.latestForDiscovery4c433ef5-3937-4530-8252-cca17d715747
rioxxterms.project.funder-nameNSERC Discovery Grants Programfr
rioxxterms.project.funder-nameFonds de Recherche du Québec - Nature et Technologiesfr
rioxxterms.versionVersion of Record (VoR)fr
rioxxterms.version-of-recordhttps://doi.org/10.1016/j.cbpa.2016.05.021fr
Fichiers
Bundle original
Voici les éléments 1 - 1 sur 1
Vignette d'image
Nom :
21-s2.0-S1367593116300576-main.pdf
Taille :
997.94 KB
Format :
Adobe Portable Document Format
Description :
Télécharger
Collections
Articles publiés dans des revues avec comité de lecture