Publication : Interplay of geometric cues and RGD/BMP-2 crosstalk in directing stem cell fate
bul.description.provenance | lf cl | fr |
bul.rights.dateAccepPubl | 2017-08-21 | fr |
bul.rights.periodeEmbargo | P1Y | fr |
bul.rights.typeDate | datePublication | fr |
dc.contributor.author | Bilem, Ibrahim | |
dc.contributor.author | Laroche, Gaétan | |
dc.contributor.author | Plawinski, Laurent | |
dc.contributor.author | Chevallier, Pascale | |
dc.contributor.author | Sone, E. (Eli) | |
dc.contributor.author | Durrieu, Marie-Christine | |
dc.date.accessioned | 2019-07-23T21:31:35Z | |
dc.date.available | 2019-07-23T21:31:35Z | |
dc.date.issued | 2017-08-21 | |
dc.description.abstract | Within the native microenvironment, extracellular matrix (ECM) components are thought to display a complex and heterogeneous distribution, spanning several length scales. Herein, the objective is to mimic, in vitro, the hierarchical organization of proteins and growth factors as well as their crosstalk. Photolithography technique was used to adjacently pattern geometrically defined regions of RGD and BMP-2 mimetic peptides onto glass substrates. These ECM-derived ligands are known to jointly regulate mesenchymal stem cells (MSCs) osteogenic differentiation. By manipulating the spatial distribution of dually grafted peptides, the extent of human MSCs osteogenic differentiation was significantly affected, depending on the shape of peptide micropatterns. Our data highlight the existence of a strong interplay between geometric cues and biochemical signals. Such in vitro systems provide a valuable tool to investigate mechanisms by which multiple ECM cues overlap to regulate stem cell fate, thereby contributing to the design of bioinspired biomaterials for bone tissue engineering applications. | fr |
dc.identifier.doi | 10.1021/acsbiomaterials.7b00279 | fr |
dc.identifier.issn | 2373-9878 | fr |
dc.identifier.uri | http://hdl.handle.net/20.500.11794/35605 | |
dc.language | eng | fr |
dc.publisher | American Chemical Society | fr |
dc.rights | http://purl.org/coar/access_right/c_abf2 | |
dc.subject | Chemical micropatterning | fr |
dc.subject | BMP-2 mimetic peptide | fr |
dc.subject | Adhesive ligands | fr |
dc.subject | RGD/BMP-2 crosstalk | fr |
dc.subject | Stem cell niche | fr |
dc.subject | Bone tissue engineering | fr |
dc.subject.rvm | Protéines de la matrice extracellulaire | fr |
dc.subject.rvm | Facteurs de croissance | fr |
dc.subject.rvm | Ligands (Biochimie) | fr |
dc.subject.rvm | Cellules souches mésenchymateuses | fr |
dc.subject.rvm | Peptides | fr |
dc.subject.rvm | Os compact | fr |
dc.subject.rvm | Génie tissulaire | fr |
dc.title | Interplay of geometric cues and RGD/BMP-2 crosstalk in directing stem cell fate | fr |
dc.type | article de recherche | |
dc.type.legacy | COAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche | fr |
dcterms.bibliographicCitation | ACS Biomaterials Science & Engineering, Vol. 3 (10), 2514-2523 (2017) | fr |
dspace.accessstatus.time | 2024-03-26 18:01:02 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 199149cd-b41d-45fa-b659-28625490c6ec | |
relation.isAuthorOfPublication | 7207871e-32e9-4680-a0f1-6ce126aebe57 | |
relation.isAuthorOfPublication | eaba009b-0f2b-4d24-8a89-43d89fce30a9 | |
relation.isAuthorOfPublication.latestForDiscovery | 199149cd-b41d-45fa-b659-28625490c6ec | |
relation.isResourceTypeOfPublication | 4c433ef5-3937-4530-8252-cca17d715747 | |
relation.isResourceTypeOfPublication.latestForDiscovery | 4c433ef5-3937-4530-8252-cca17d715747 | |
rioxxterms.project.funder-name | National Science and Engineering Research Council of Canada | fr |
rioxxterms.project.funder-name | Agence Nationale de la Recherche | fr |
rioxxterms.version | Accepted Manuscript (AM) | fr |
rioxxterms.version-of-record | https://doi.org/10.1021/acsbiomaterials.7b00279 | fr |
Fichiers
Bundle original
1 - 1 sur 1
En cours de chargement...
- Nom :
- Interplay of geometric cues and RGDBMP-2 crosstalk in directing stem cell fate.pdf
- Taille :
- 6.49 MB
- Format :
- Adobe Portable Document Format