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Publication :
Interplay of geometric cues and RGD/BMP-2 crosstalk in directing stem cell fate

bul.description.provenancelf clfr
bul.rights.dateAccepPubl2017-08-21fr
bul.rights.periodeEmbargoP1Yfr
bul.rights.typeDatedatePublicationfr
dc.contributor.authorBilem, Ibrahim
dc.contributor.authorLaroche, Gaétan
dc.contributor.authorPlawinski, Laurent
dc.contributor.authorChevallier, Pascale
dc.contributor.authorSone, E. (Eli)
dc.contributor.authorDurrieu, Marie-Christine
dc.date.accessioned2019-07-23T21:31:35Z
dc.date.available2019-07-23T21:31:35Z
dc.date.issued2017-08-21
dc.description.abstractWithin the native microenvironment, extracellular matrix (ECM) components are thought to display a complex and heterogeneous distribution, spanning several length scales. Herein, the objective is to mimic, in vitro, the hierarchical organization of proteins and growth factors as well as their crosstalk. Photolithography technique was used to adjacently pattern geometrically defined regions of RGD and BMP-2 mimetic peptides onto glass substrates. These ECM-derived ligands are known to jointly regulate mesenchymal stem cells (MSCs) osteogenic differentiation. By manipulating the spatial distribution of dually grafted peptides, the extent of human MSCs osteogenic differentiation was significantly affected, depending on the shape of peptide micropatterns. Our data highlight the existence of a strong interplay between geometric cues and biochemical signals. Such in vitro systems provide a valuable tool to investigate mechanisms by which multiple ECM cues overlap to regulate stem cell fate, thereby contributing to the design of bioinspired biomaterials for bone tissue engineering applications.fr
dc.identifier.doi10.1021/acsbiomaterials.7b00279fr
dc.identifier.issn2373-9878fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/35605
dc.languageengfr
dc.publisherAmerican Chemical Societyfr
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectChemical micropatterningfr
dc.subjectBMP-2 mimetic peptidefr
dc.subjectAdhesive ligandsfr
dc.subjectRGD/BMP-2 crosstalkfr
dc.subjectStem cell nichefr
dc.subjectBone tissue engineeringfr
dc.subject.rvmProtéines de la matrice extracellulairefr
dc.subject.rvmFacteurs de croissancefr
dc.subject.rvmLigands (Biochimie)fr
dc.subject.rvmCellules souches mésenchymateusesfr
dc.subject.rvmPeptidesfr
dc.subject.rvmOs compactfr
dc.subject.rvmGénie tissulairefr
dc.titleInterplay of geometric cues and RGD/BMP-2 crosstalk in directing stem cell fatefr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationACS Biomaterials Science & Engineering, Vol. 3 (10), 2514-2523 (2017)fr
dspace.accessstatus.time2024-03-26 18:01:02
dspace.entity.typePublication
relation.isAuthorOfPublication199149cd-b41d-45fa-b659-28625490c6ec
relation.isAuthorOfPublication7207871e-32e9-4680-a0f1-6ce126aebe57
relation.isAuthorOfPublicationeaba009b-0f2b-4d24-8a89-43d89fce30a9
relation.isAuthorOfPublication.latestForDiscovery199149cd-b41d-45fa-b659-28625490c6ec
relation.isResourceTypeOfPublication4c433ef5-3937-4530-8252-cca17d715747
relation.isResourceTypeOfPublication.latestForDiscovery4c433ef5-3937-4530-8252-cca17d715747
rioxxterms.project.funder-nameNational Science and Engineering Research Council of Canadafr
rioxxterms.project.funder-nameAgence Nationale de la Recherchefr
rioxxterms.versionAccepted Manuscript (AM)fr
rioxxterms.version-of-recordhttps://doi.org/10.1021/acsbiomaterials.7b00279fr

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