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Tissue-Engineered Vascular Adventitia with Vasa Vasorum Improves Graft Integration and Vascularization Through Inosculation

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bul.description.provenancenag spbfr
bul.rights.dateAccepPubl2010-05-05fr
bul.rights.periodeEmbargoforeverfr
bul.rights.raisonEmbargoInfiniPour que le document soit diffusé en libre accès, en accord avec le délai prescrit par l’éditeur de Tissue Engineering, il faudrait déposer la version acceptée pour publication, incluant toutes les modifications demandées, mais sans la mise en page de la revue. Pour ce faire, effectuez une demande de modification à l’aide de la liste des dépôts diffusés à partir du tableau de suivi.fr
bul.rights.typeDatedatePublicationfr
dc.audience.peerreview1fr
dc.contributor.authorGuillemette, Maxime.
dc.contributor.authorPerron, Cindy
dc.contributor.authorGermain, Lucie
dc.contributor.authorLabbé, Raymond
dc.contributor.authorAuger, François A.
dc.contributor.authorGauvin, Robert
dc.date.accessioned2018-01-29T21:25:48Z
dc.date.available9999-12-31
dc.date.issued2010-05-05
dc.description.abstractTissue-engineered blood vessel is one of the most promising living substitutes for coronary and peripheral artery bypass graft surgery. However, one of the main limitations in tissue engineering is vascularization of the construct before implantation. Such a vascularization could play an important role in graft perfusion and host integration of tissue-engineered vascular adventitia. Using our self-assembly approach, we developed a method to vascularize tissue-engineered blood vessel constructs by coculturing endothelial cells in a fibroblast-laden tissue sheet. After subcutaneous implantation, enhancement of graft integration within the surrounding environment was noted after 48 h and an important improvement in blood circulation of the grafted tissue at 1 week postimplantation. The distinctive branching structure of end arteries characterizing the in vivo adventitial vasa vasorum has also been observed in long-term postimplantation follow-up. After a 90-day implantation period, hybrid vessels containing human and mouse endothelial cells were still perfused. Characterization of the mechanical properties of both control and vascularized adventitia demonstrated that the ultimate tensile strength, modulus, and failure strain were in the same order of magnitude of a pig coronary artery. The addition of a vasa vasorum to the tissue-engineered adventitia did not influence the burst pressure of these constructs. Hence, the present results indicate a promising answer to the many challenges associated with the in vitro vascularization and in vivo integration of many different tissue-engineered substitutes. en
dc.identifier.doi10.1089/ten.tea.2009.0612fr
dc.identifier.issn1937335Xfr
dc.identifier.pubmed20455774fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/16746
dc.languageengfr
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subjectAdventice (Histologie)fr
dc.subject.rvmVaisseaux sanguinsfr
dc.subject.rvmGénie tissulairefr
dc.subject.rvmNéovascularisationfr
dc.subject.rvmVasa vasorumfr
dc.subject.rvmGreffe (Chirurgie)fr
dc.titleTissue-Engineered Vascular Adventitia with Vasa Vasorum Improves Graft Integration and Vascularization Through Inosculationfr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationTissue engineering. Part A, Vol. 16 (8), 2617-2626 (2010)fr
dspace.accessstatus.time2023-05-25 18:25:40
dspace.entity.typePublication
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relation.isAuthorOfPublication978ec9c6-43e3-4ecb-8f9c-81c1c6b1062a
relation.isAuthorOfPublicationa25af9de-b03e-45e5-bd9f-5dc8c250fcf8
relation.isAuthorOfPublication.latestForDiscovery0b5e7909-d4ba-4b7d-a31a-f9b3fbf54cca
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rioxxterms.project.funder-nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder-nameCanadian Research Chair on Stem Cellsfr
rioxxterms.project.funder-nameTissue Engineering from Canadian Institutes of Health Research.fr
rioxxterms.versionVersion of Record (VoR)fr
rioxxterms.version-of-recordhttps://doi.org/10.1089/ten.tea.2009.0612fr
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