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Publication :
UGT genomic diversity : beyond gene duplication

bul.description.provenancelffr_CA
bul.description.provenancespbfr_CA
bul.rights.dateAccepPubl2009-10-26fr_CA
bul.rights.periodeEmbargoP1Yfr_CA
bul.rights.typeDatedatePublicationfr_CA
dc.audiencePharmaciensfr_CA
dc.audienceBiochimistesfr_CA
dc.audienceProfesseurs (Enseignement supérieur)fr_CA
dc.audienceÉtudiantsfr_CA
dc.audienceDoctorantsfr_CA
dc.contributor.authorLévesque, Éric
dc.contributor.authorBellemare, Judith.
dc.contributor.authorHarvey, Mario.
dc.contributor.authorMénard, Vincent
dc.contributor.authorGuillemette, Chantal
dc.date.accessioned2016-09-28T13:33:43Z
dc.date.available2016-09-28T13:33:43Z
dc.date.issued2009-10-26
dc.description.abstractThe human uridine diphospho (UDP)-glucuronosyltransferase (UGT) superfamily comprises enzymes responsible for a major biotransformation phase II pathway: the glucuronidation process. The UGT enzymes are located in the endoplasmic reticulum of almost all tissues, where they catalyze the inactivation of several endogenous and exogenous molecules, including bilirubin, sex steroids, numerous prescribed drugs, and environmental toxins. This metabolic pathway is particularly variable. The influence of inheritable polymorphisms in human UGT-encoding genes has been extensively documented and was shown to be responsible for a fraction of the observed phenotypic variability. Other key genomic processes are likely underlying this diversity; these include copy-number variations, epigenetic factors, and newly discovered splicing mechanisms. This review will discuss novel molecular aspects that may be determinant to UGT phenotypes.fr_CA
dc.identifier.doi10.3109/03602530903210682fr_CA
dc.identifier.issn0360-2532fr_CA
dc.identifier.pubmed19857043fr_CA
dc.identifier.urihttp://hdl.handle.net/20.500.11794/10528
dc.languageengfr_CA
dc.publisherInforma Healthcarefr_CA
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectGlucuronosyltransferasefr_CA
dc.subjectUGTfr_CA
dc.subjectAlternative splicingfr_CA
dc.subjectCopy-number variationfr_CA
dc.subjectPolymorphismsfr_CA
dc.subjectEpigeneticsfr_CA
dc.subjectPharmacogenomics,fr_CA
dc.subject.rvmGlucuronosyltransférasefr_CA
dc.subject.rvmÉpissage alternatiffr_CA
dc.subject.rvmPharmacogénomiquefr_CA
dc.subject.rvmPolymorphisme de nucléotide simplefr_CA
dc.subject.rvmÉpigénétiquefr_CA
dc.titleUGT genomic diversity : beyond gene duplicationfr_CA
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche
dcterms.bibliographicCitationDrug metabolism reviews, Vol. 42 (1), 24–44 (2010)fr_CA
dspace.accessstatus.time2024-03-25 18:12:11
dspace.entity.typePublication
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rioxxterms.projectMOP-42392, MOP-84223fr_CA
rioxxterms.project.funder-nameCanadian Institutes of Health Researchfr_CA
rioxxterms.versionAccepted Manuscript (AM)fr_CA
rioxxterms.version-of-recordhttps://doi.org/10.3109/03602530903210682fr_CA

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