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Early development of calcific aortic valve disease and left ventricular hypertrophy in a mouse model of combined dyslipidemia and type 2 diabetes mellitus.

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bul.description.provenanceecfr_CA
bul.description.provenancespbfr_CA
bul.rights.dateAccepPubl2014-08-14fr_CA
bul.rights.periodeEmbargoforeverfr_CA
bul.rights.raisonEmbargoInfiniPour que le document soit diffusé en libre accès, en accord avec le délai prescrit par l’éditeur de Arteriosclerosis, thrombosis, and vascular biology, il faudrait déposer la version acceptée par le comité de lecture, incluant toutes les corrections, sans la mise en page de la revue. Pour ce faire, effectuez une demande de modification à l’aide de la liste des dépôts diffusés à partir du tableau de suivi.fr_CA
bul.rights.typeDatedatePublicationfr_CA
dc.audienceProfesseurs (Enseignement supérieur)fr_CA
dc.audienceÉtudiantsfr_CA
dc.audienceDoctorantsfr_CA
dc.audienceCardiologuesfr_CA
dc.contributor.authorLachance, Dominic.
dc.contributor.authorBouchareb, Rihab
dc.contributor.authorKohen Avramoglu, Rita
dc.contributor.authorFournier, Dominique
dc.contributor.authorMarette, André
dc.contributor.authorBoulanger, Marie-Chloé
dc.contributor.authorLe Quang, Khai
dc.contributor.authorEl Husseini, Diala
dc.contributor.authorFang, Xiang Ping
dc.contributor.authorPibarot, Philippe
dc.contributor.authorDeshaies, Yves
dc.contributor.authorSweeney, Gary
dc.contributor.authorMathieu, Patrick
dc.contributor.authorLaplante, Marc André
dc.date.accessioned2016-06-20T18:26:14Z
dc.date.available9999-12-31
dc.date.issued2014-08-14
dc.description.abstractObjective—This study aimed to determine the potential impact of type 2 diabetes mellitus on left ventricular dysfunction and the development of calcified aortic valve disease using a dyslipidemic mouse model prone to developing type 2 diabetes mellitus. Approach and Results—When compared with nondiabetic LDLr-/-/ApoB100/100, diabetic LDLr-/-/ApoB100/100/IGF-II mice exhibited similar dyslipidemia and obesity but developed type 2 diabetes mellitus when fed a high-fat/sucrose/cholesterol diet for 6 months. LDLr-/-/ApoB100/100/IGF-II mice showed left ventricular hypertrophy versus C57BL6 but not LDLr-/-/ ApoB100/100 mice. Transthoracic echocardiography revealed significant reductions in both left ventricular systolic fractional shortening and diastolic function in high-fat/sucrose/cholesterol fed LDLr-/-/ApoB100/100/IGF-II mice when compared with LDLr-/-/ApoB100/100. Importantly, we found that peak aortic jet velocity was significantly increased in LDLr-/-/ApoB100/100/ IGF-II mice versus LDLr-/-/ApoB100/100 animals on the high-fat/sucrose/cholesterol diet. Microtomography scans and Alizarin red staining indicated calcification in the aortic valves, whereas electron microscopy and energy dispersive x-ray spectroscopy further revealed mineralization of the aortic leaflets and the presence of inflammatory infiltrates in diabetic mice. Studies showed upregulation of hypertrophic genes (anp, bnp, b-mhc) in myocardial tissues and of osteogenic genes (spp1, bglap, runx2) in aortic tissues of diabetic mice. Conclusions—We have established the diabetes mellitus –prone LDLr-/-/ApoB100/100/IGF-II mouse as a new model of calcified aortic valve disease. Our results are consistent with the growing body of clinical evidence that the dysmetabolic state of type 2 diabetes mellitus contributes to early mineralization of the aortic valve and calcified aortic valve disease pathogenesis.fr_CA
dc.identifier.doi10.1161/ATVBAHA.114.304205fr_CA
dc.identifier.issn1079-5642fr_CA
dc.identifier.pubmed25231636fr_CA
dc.identifier.urihttp://hdl.handle.net/20.500.11794/6891
dc.languageengfr_CA
dc.publisherAmerican Heart Associationfr_CA
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subjectaortic valve stenosisfr_CA
dc.subjectdiabetes mellitus, type 2fr_CA
dc.subjectinflammationfr_CA
dc.subjectobesityfr_CA
dc.subject.rvmAorte -- Rétrécissementfr_CA
dc.subject.rvmCœur -- Ventricule gauche -- Hypertrophiefr_CA
dc.subject.rvmDyslipidémiesfr_CA
dc.subject.rvmDiabète non insulinodépendantfr_CA
dc.subject.rvmObésitéfr_CA
dc.subject.rvmSouris (Animal de laboratoire)fr_CA
dc.subject.rvmInsuffisance ventriculaire gauchefr_CA
dc.titleEarly development of calcific aortic valve disease and left ventricular hypertrophy in a mouse model of combined dyslipidemia and type 2 diabetes mellitus.fr_CA
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche
dcterms.bibliographicCitationArteriosclerosis, thrombosis, and vascular biology, Vol. 34, 2283-2291 (2014)fr_CA
dspace.accessstatus.time2023-05-25 18:17:02
dspace.entity.typePublication
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rioxxterms.project161971, 245048fr_CA
rioxxterms.project.funder-nameirscfr_CA
rioxxterms.versionVersion of Record (VoR)fr_CA
rioxxterms.version-of-recordhttps://doi.org/10.1161/ATVBAHA.114.304205fr_CA
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