Publication : Post-exercise heart rate recovery and mortality in chronic obstructive pulmonary disease
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Date
2005-07-07
Direction de publication
Direction de recherche
Titre de la revue
ISSN de la revue
Titre du volume
Éditeur
Bailliere Tindall
Résumé
Abnormal heart rate recovery (HRR) after exercise, a marker of cardiac
autonomic dysfunction, is associated with poor prognosis in various populations. As
chronic obstructive pulmonary disease (COPD) is associated with cardiac autonomic
dysfunction, we tested the hypothesis that patients with COPD have a lower HRR
than healthy people, and evaluated whether a delay in HRR is associated with an
increased risk of mortality in COPD. The records of 147 COPD patients were reviewed
(65.179.1 years, mean7SD, 42 women/105 men, forced expiratory volume in 1 s
(FEV1): 42715% predicted) and compared to 25 healthy subjects (61.674.5 years, 5
women/20 men, FEV1: 100714% predicted) during recovery after an exercise test.
Heart rate was measured at peak exercise and at 1-min recovery, the difference
between the two being defined as HRR (1179 beats in COPD patients vs. 2079 beats
in healthy subjects, Po0:0001). During a mean follow-up of 43.1722.0 months, 32
patients died. Abnormal HRR (p14 beats) was a strong predictor of mortality in
COPD patients (adjusted hazard ratio: 5.12, 95% CI [1.54–17.00]). In conclusion,
COPD patients have a lower HRR than healthy subjects, and have a worse prognosis
when presenting abnormal HRR
Description
Revue
Respiratory Medicine, Vol. 99 (7), 877–886 (2005)
DOI
10.1016/j.rmed.2004.11.012
URL vers la version publiée
Mots-clés
COPD , Survival , Autonomic dysfunction
Citation
Type de document
article de recherche