Publication : Validation of aortic valve calcium quantification thresholds measured by computed tomography in Asian patients with calcific aortic stenosis
bul.description.provenance | noadg spbar | fr |
bul.rights.dateAccepPubl | 2021-06-25 | fr |
bul.rights.periodeEmbargo | forever | fr |
bul.rights.raisonEmbargoInfini | Pour que le document soit diffusé en libre accès, en accord avec le délai prescrit par l’éditeur de European Heart Journal. Cardiovascular Imaging, il faudrait déposer la version acceptée pour publication, incluant toutes les modifications demandées, mais sans la mise en page de la revue. Pour ce faire, effectuez une demande de modification à l’aide de la liste des dépôts diffusés à partir du tableau de suivi. | fr |
bul.rights.typeDate | datePublication | fr |
dc.contributor.author | Guzzetti, Ezequiel | |
dc.contributor.author | Oh, Kyung Jin | |
dc.contributor.author | Shen, Mylène | |
dc.contributor.author | Pibarot, Philippe | |
dc.contributor.author | Dweck, Marc R. | |
dc.contributor.author | Clavel, Marie-Annick | |
dc.contributor.author | Poh, Kian Keong | |
dc.contributor.author | Tastet, Lionel | |
dc.contributor.author | Abbas, Amr E. | |
dc.contributor.author | Mando, Ramy | |
dc.contributor.author | Pressman, Gregg | |
dc.contributor.author | Brito, Daniel | |
dc.contributor.author | Pawade, Tania | |
dc.contributor.author | Falconi, Mariano Luis | |
dc.contributor.author | Arenaza, Diego Perez de | |
dc.contributor.author | Kong, William | |
dc.date.accessioned | 2021-07-30T13:43:49Z | |
dc.date.available | 9999-12-31 | |
dc.date.issued | 2021-06-25 | |
dc.description.abstract | Aims Sex-specific thresholds of aortic valve calcification (AVC) have been proposed and validated in Caucasians. Thus, we aimed to validate their accuracy in Asians. Methods and results Patients with calcific aortic stenosis (AS) from seven international centres were included. Exclusion criteria were ≥moderate aortic/mitral regurgitation and bicuspid valve. Optimal AVC and AVC-density sex-specific thresholds for severe AS were obtained in concordant grading and normal flow patients (CG/NF). We included 1263 patients [728 (57%) Asians, 573 (45%) women, 837 (66%) with CG/NF]. Mean gradient was 48 (26–64) mmHg and peak aortic velocity 4.5 (3.4–5.1) m/s. Optimal AVC thresholds were: 2145 Agatston Units (AU) in men and 1301 AU in women for Asians; and 1885 AU in men and 1129 AU in women for Caucasians. Overall, accuracy (% correctly classified) was high and comparable either using optimal or guidelines’ thresholds (2000 AU in men, 1200 AU in women). However, accuracy was lower in Asian women vs. Caucasian women (76–78% vs. 94–95%; P < 0.001). Accuracy of AVC-density (476 AU/cm2 in men and 292 AU/cm2 in women) was comparable to absolute AVC in Caucasians (91% vs. 91%, respectively, P = 0.74), but higher than absolute AVC in Asians (87% vs. 81%, P < 0.001). There was no interaction between AVC/AVC-density and ethnicity (all P > 0.41) with regards to AS haemodynamic severity. Conclusion AVC thresholds defining severe AS are comparable in Asian and Caucasian populations, and similar to those proposed in the guidelines. However, accuracy of AVC to identify severe AS in Asians (especially women) is sub-optimal. Therefore, the use of AVC-density is preferable in Asians. | fr |
dc.identifier.doi | https://doi.org/10.1093/ehjci/jeab116 | fr |
dc.identifier.issn | 2047-2404 | fr |
dc.identifier.pubmed | 34172988 | fr |
dc.identifier.uri | http://hdl.handle.net/20.500.11794/69761 | |
dc.language | eng | fr |
dc.publisher | Oxford University Press | fr |
dc.rights | http://purl.org/coar/access_right/c_16ec | |
dc.subject | Aortic stenosis | fr |
dc.subject | Calcification | fr |
dc.subject | Computed tomography | fr |
dc.subject | Echocardiography | fr |
dc.subject.rvm | Aorte -- Rétrécissement -- Calcification | fr |
dc.subject.rvm | Tomodensitométrie | fr |
dc.subject.rvm | Asiatiques | fr |
dc.title | Validation of aortic valve calcium quantification thresholds measured by computed tomography in Asian patients with calcific aortic stenosis | fr |
dc.type | article de recherche | |
dc.type.legacy | COAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche | fr |
dcterms.bibliographicCitation | European Heart Journal. Cardiovascular Imaging, 1-10 (2021) | fr |
dspace.accessstatus.time | 2024-03-25 18:03:17 | |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication.latestForDiscovery | 1324408e-e205-485a-95b8-0bf86861249d | |
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rioxxterms.project.funder-name | Quebec Heart and Lung University Institute Foundation | fr |
rioxxterms.project.funder-name | British Heart Foundation | fr |
rioxxterms.version | Version of Record (VoR) | fr |
rioxxterms.version-of-record | https://doi.org/10.1093/ehjci/jeab116 | fr |
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