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Publication :
Long-term adiposity changes are related to a glucocorticoid receptor polymorphism in young females

bul.description.provenanceemo spbfr
bul.rights.dateAccepPubl2003-07-01fr
bul.rights.periodeEmbargoforeverfr
bul.rights.raisonEmbargoInfiniPour que le document soit diffusé en libre accès, en accord avec le délai prescrit par l’éditeur de Journal of Clinical Endocrinology and Metabolism, il faudrait déposer la version acceptée pour publication, incluant toutes les modifications demandées, mais sans la mise en page de la revue. Pour ce faire, effectuez une demande de modification à l’aide de la liste des dépôts diffusés à partir du tableau de suivi.fr
bul.rights.typeDatedatePublicationfr
dc.audienceProfesseurs (Enseignement supérieur)fr
dc.audienceÉtudiantsfr
dc.audienceDoctorantsfr
dc.audienceNutritionnistesfr
dc.contributor.authorDrapeau, Vicky
dc.contributor.authorBouchard, Claude
dc.contributor.authorPérusse, Louis
dc.contributor.authorTremblay, Angelo
dc.contributor.authorBouchard, Luigi
dc.contributor.authorDesprés, Jean-Pierre
dc.coverage.spatialQuébec (Province)fr
dc.date.accessioned2017-09-18T19:42:31Z
dc.date.available9999-12-31
dc.date.issued2003-07-01
dc.description.abstractMale and female preadolescents and adolescents who participated in phase 1 of the Québec Family Study, and who were retested about 12 yr later, were recruited and subdivided on the basis of a genetic variant within the intron 2 of the glucocorticoid receptor (GRL IVS2-BclI). The increase in sc adiposity over the 12-yr follow-up period in the 4.5/2.3 genotype female subgroup was more than twice that observed in the 4.5/4.5 and the 2.3/2.3 genotype subgroups (P < 0.01). The statistical significance of this difference was essentially unchanged after adjusting for changes, over time, in percent dietary energy as fat, alcohol consumption, and participation in vigorous physical activity. In male subjects, the same trend was found, but it did not reach statistical significance. In conclusion, this study suggests that a significant interaction effect exists between variation in the glucocorticoid receptor gene and body fat gain in female subjects experiencing the transition between adolescence and adulthood. Further research will, however, be necessary to characterize the lifestyle factors promoting fat accumulation, over time, among genetically susceptible individuals.fr
dc.identifier.doi10.1210/jc.2002-021521fr
dc.identifier.issn0021-972Xfr
dc.identifier.pubmed12843156fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/15417
dc.languageengfr
dc.publisherOxford Academicfr
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subjectObesityfr
dc.subjectPhysical activityfr
dc.subjectPolymorphismfr
dc.subjectDietfr
dc.subjectAdolescentfr
dc.subjectAdultfr
dc.subjectAlcohol drinkingfr
dc.subjectFollow-upfr
dc.subjectGenesfr
dc.subjectGenotypefr
dc.subjectIntronsfr
dc.subjectLife stylefr
dc.subjectGlucocorticoid receptorfr
dc.subjectGeneticsfr
dc.subjectFamily studyfr
dc.subjectBody fatfr
dc.subjectPre-teenfr
dc.subject.rvmGlucocorticoïdes -- Récepteursfr
dc.subject.rvmPolymorphisme génétiquefr
dc.subject.rvmObésitéfr
dc.subject.rvmGraisse (Physiologie)fr
dc.subject.rvmJeunes femmesfr
dc.subject.rvmAdolescentesfr
dc.titleLong-term adiposity changes are related to a glucocorticoid receptor polymorphism in young femalesfr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationThe Journal of clinical endocrinology and metabolism, Vol. 88 (7), 3141–3145 (2003)fr
dspace.accessstatus.time2024-03-23 18:05:55
dspace.entity.typePublication
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rioxxterms.project.funder-nameMedical Research Council Canadafr
rioxxterms.project.funder-nameGeorge A. Bray Chair in Nutritionfr
rioxxterms.project.funder-nameCanada Research Chair in Physical Activity, Nutrition and Energy Balancefr
rioxxterms.versionVersion of Record (VoR)fr
rioxxterms.version-of-recordhttp://dx.doi.org/10.1210/jc.2002-021521fr

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