Publication : Long-term adiposity changes are related to a glucocorticoid receptor polymorphism in young females
bul.description.provenance | emo spb | fr |
bul.rights.dateAccepPubl | 2003-07-01 | fr |
bul.rights.periodeEmbargo | forever | fr |
bul.rights.raisonEmbargoInfini | Pour que le document soit diffusé en libre accès, en accord avec le délai prescrit par l’éditeur de Journal of Clinical Endocrinology and Metabolism, il faudrait déposer la version acceptée pour publication, incluant toutes les modifications demandées, mais sans la mise en page de la revue. Pour ce faire, effectuez une demande de modification à l’aide de la liste des dépôts diffusés à partir du tableau de suivi. | fr |
bul.rights.typeDate | datePublication | fr |
dc.audience | Professeurs (Enseignement supérieur) | fr |
dc.audience | Étudiants | fr |
dc.audience | Doctorants | fr |
dc.audience | Nutritionnistes | fr |
dc.contributor.author | Drapeau, Vicky | |
dc.contributor.author | Bouchard, Claude | |
dc.contributor.author | Pérusse, Louis | |
dc.contributor.author | Tremblay, Angelo | |
dc.contributor.author | Bouchard, Luigi | |
dc.contributor.author | Després, Jean-Pierre | |
dc.coverage.spatial | Québec (Province) | fr |
dc.date.accessioned | 2017-09-18T19:42:31Z | |
dc.date.available | 9999-12-31 | |
dc.date.issued | 2003-07-01 | |
dc.description.abstract | Male and female preadolescents and adolescents who participated in phase 1 of the Québec Family Study, and who were retested about 12 yr later, were recruited and subdivided on the basis of a genetic variant within the intron 2 of the glucocorticoid receptor (GRL IVS2-BclI). The increase in sc adiposity over the 12-yr follow-up period in the 4.5/2.3 genotype female subgroup was more than twice that observed in the 4.5/4.5 and the 2.3/2.3 genotype subgroups (P < 0.01). The statistical significance of this difference was essentially unchanged after adjusting for changes, over time, in percent dietary energy as fat, alcohol consumption, and participation in vigorous physical activity. In male subjects, the same trend was found, but it did not reach statistical significance. In conclusion, this study suggests that a significant interaction effect exists between variation in the glucocorticoid receptor gene and body fat gain in female subjects experiencing the transition between adolescence and adulthood. Further research will, however, be necessary to characterize the lifestyle factors promoting fat accumulation, over time, among genetically susceptible individuals. | fr |
dc.identifier.doi | 10.1210/jc.2002-021521 | fr |
dc.identifier.issn | 0021-972X | fr |
dc.identifier.pubmed | 12843156 | fr |
dc.identifier.uri | http://hdl.handle.net/20.500.11794/15417 | |
dc.language | eng | fr |
dc.publisher | Oxford Academic | fr |
dc.rights | http://purl.org/coar/access_right/c_16ec | |
dc.subject | Obesity | fr |
dc.subject | Physical activity | fr |
dc.subject | Polymorphism | fr |
dc.subject | Diet | fr |
dc.subject | Adolescent | fr |
dc.subject | Adult | fr |
dc.subject | Alcohol drinking | fr |
dc.subject | Follow-up | fr |
dc.subject | Genes | fr |
dc.subject | Genotype | fr |
dc.subject | Introns | fr |
dc.subject | Life style | fr |
dc.subject | Glucocorticoid receptor | fr |
dc.subject | Genetics | fr |
dc.subject | Family study | fr |
dc.subject | Body fat | fr |
dc.subject | Pre-teen | fr |
dc.subject.rvm | Glucocorticoïdes -- Récepteurs | fr |
dc.subject.rvm | Polymorphisme génétique | fr |
dc.subject.rvm | Obésité | fr |
dc.subject.rvm | Graisse (Physiologie) | fr |
dc.subject.rvm | Jeunes femmes | fr |
dc.subject.rvm | Adolescentes | fr |
dc.title | Long-term adiposity changes are related to a glucocorticoid receptor polymorphism in young females | fr |
dc.type | article de recherche | |
dc.type.legacy | COAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche | fr |
dcterms.bibliographicCitation | The Journal of clinical endocrinology and metabolism, Vol. 88 (7), 3141–3145 (2003) | fr |
dspace.accessstatus.time | 2024-03-23 18:05:55 | |
dspace.entity.type | Publication | |
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rioxxterms.project.funder-name | Medical Research Council Canada | fr |
rioxxterms.project.funder-name | George A. Bray Chair in Nutrition | fr |
rioxxterms.project.funder-name | Canada Research Chair in Physical Activity, Nutrition and Energy Balance | fr |
rioxxterms.version | Version of Record (VoR) | fr |
rioxxterms.version-of-record | http://dx.doi.org/10.1210/jc.2002-021521 | fr |
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