Publication :
Cognitive structure from childhood to adulthood in kindreds densely affected by schizophrenia and bipolar disorder

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Date
2015-07-23
Direction de publication
Direction de recherche
Titre de la revue
ISSN de la revue
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Éditeur
Elsevier Ltd.
Projets de recherche
Structures organisationnelles
Numéro de revue
Résumé
The developmental aspects of cognitive structures from childhood until adulthood and across different levels of risk for psychopathology have been little studied. The aim of the current study was to explore the cognitive factorial structure in subsamples from highly familial and densely affected kindreds of schizophrenia and bipolar disorder – i.e. affected adult members, non-affected adult members and highrisk youth. The same neuropsychological battery was administered in a sample of 480 participants: schizophrenia and bipolar patients (n¼51), young high-risk offspring (n¼61), non-affected adult relatives of patients (n¼96), and controls (n¼272). Exploratory Factorial Analysis was performed in the control sample and yielded a 5-factor solution: verbal comprehension, processing speed/working memory, visual learning and memory, verbal learning and memory, reasoning and problem solving. Confirmatory factor analysis indicated that the hierarchical 5-factor solution was well suited for the young high-risk offspring, the non-affected adult relatives of patient and the patients. A hierarchical model with a “g” factor was a good fit for all subsamples. These results suggest that cognitive impairments may aggregate in highly familial individuals.
Description
Revue
Psychiatry research, Vol. 229 (1-2), 101-108 (2015)
DOI
10.1016/j.psychres.2015.07.063
URL vers la version publiée
Mots-clés
Neuropsychology , Exploratory Factorial Analysis , Confirmatory Factorial Analysis , g Factor , Children , Adolescents , Adults
Citation
Type de document
article de recherche