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Genetic risk prediction of the plasma triglyceride response to independent supplementations with eicosapentaenoic and docosahexaenoic acids : the 2 ComparED study

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bul.description.provenancelf spbfr
bul.rights.dateAccepPubl2020-06-15fr
bul.rights.periodeEmbargoP0Mfr
bul.rights.typeDatedatePublicationfr
dc.contributor.authorGuénard, Frédéric
dc.contributor.authorVallée-Marcotte, Bastien
dc.contributor.authorToro Martin, Juan de
dc.contributor.authorLamarche, Benoît
dc.contributor.authorAllaire, Janie
dc.contributor.authorVohl, Marie-Claude
dc.contributor.authorCouture, Patrick
dc.date.accessioned2020-08-20T09:42:19Z
dc.date.available2020-08-20T09:42:19Z
dc.date.issued2020-06-15
dc.description.abstractBackground : We previously built a genetic risk score (GRS) highly predictive of the plasma triglyceride (TG) response to an omega-3 fatty acid (n-3 FA) supplementation from marine sources. The objective of the present study was to test the potential of this GRS to predict the plasma TG responsiveness to supplementation with either eicosapentaenoic (EPA) or docosahexaenoic (DHA) acids in the Comparing EPA to DHA (ComparED) Study. Methods : The ComparED Study is a double-blind, controlled, crossover trial, with participants randomized to three supplemented phases of 10 weeks each: (1) 2.7 g/day of DHA, (2) 2.7 g/day of EPA, and (3) 3 g/day of corn oil (control), separated by 9-week washouts. The 31 SNPs used to build the previous GRS were genotyped in 122 participants of the ComparED Study using TaqMan technology. The GRS for each participant was computed by summing the number of rare alleles. Ordinal and binary logistic models, adjusted for age, sex, and body mass index, were used to calculate the ability of the GRS to predict TG responsiveness. Results : The GRS predicted TG responsiveness to EPA supplementation (p = 0.006), and a trend was observed for DHA supplementation (p = 0.08). The exclusion of participants with neutral TG responsiveness clarified the association patterns and the predictive capability of the GRS (EPA, p = 0.0003, DHA p = 0.01). Conclusion : Results of the present study suggest that the constructed GRS is a good predictor of the plasma TG response to supplementation with either DHA or EPA.fr
dc.identifier.doi10.1186/s12263-020-00669-xfr
dc.identifier.issn1555-8932fr
dc.identifier.pubmed7294612fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/40109
dc.languageengfr
dc.publisherBioMed Central Ltd.fr
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectGenetic risk scorefr
dc.subjectPlasma triglyceride levelsfr
dc.subjectOmega-3 fatty acidsfr
dc.subjectEPAfr
dc.subjectDHAfr
dc.subjectNutrigeneticsfr
dc.subject.rvmTriglycéridesfr
dc.subject.rvmAcide eicosapentaénoïquefr
dc.subject.rvmAcide docosahexaénoïquefr
dc.subject.rvmAcides gras oméga 3fr
dc.subject.rvmNutrigénomiquefr
dc.titleGenetic risk prediction of the plasma triglyceride response to independent supplementations with eicosapentaenoic and docosahexaenoic acids : the 2 ComparED studyfr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationGenes and Nutrition, Vol. 15 (article 10), 1-8 (2020)fr
dspace.accessstatus.time2023-05-25 18:00:52
dspace.entity.typePublication
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relation.isAuthorOfPublicatione63a8d1e-7b79-4d6f-ac1e-4f75a459b511
relation.isAuthorOfPublication.latestForDiscovery118048f6-7f60-4c91-afff-eb6cf5e11ca4
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rioxxterms.projectMOP-123494fr
rioxxterms.project.funder-nameCanadian Institutes of Health Researchfr
rioxxterms.versionAccepted Manuscript (AM)fr
rioxxterms.version-of-recordhttps://doi.org/10.1186/s12263-020-00669-xfr
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