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Polypharmacy and pharmacological treatment of diabetes in older individuals : a population-based study in Quebec, Canada

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ali.license-refhttps://creativecommons.org/licenses/by/4.0fr
ali.license-ref.start-date2021-01-07fr
bul.description.provenancechlac elcou28 autorité-manquante gagnon (à créer, en attente d'une réponse) et simardfr
bul.rights.dateAccepPubl2019-12-01fr
bul.rights.periodeEmbargoP0Mfr
bul.rights.typeDatedatePublicationfr
dc.audience.peerreview1fr
dc.contributor.authorPlante, Céline
dc.contributor.authorSimard, Marc
dc.contributor.authorGagnon, Marie-Ève
dc.contributor.authorSirois, Caroline
dc.coverage.spatialQuébec (Province)fr
dc.date.accessioned2021-01-15T16:36:31Z
dc.date.available2021-01-15T16:36:31Z
dc.date.issued2019-12-01
dc.description.abstractOur objectives were to describe the use of pharmacological treatments in older adults with diabetes and to identify the factors associated with the use of a combination of hypoglycemic, antihypertensive and lipid-lowering agents. Using the Quebec Integrated Chronic Disease Surveillance System, we conducted a population-based cohort study among individuals aged 66–75 years with diabetes in 2014-2015. We described the number of medications and the classes of medications used and calculated the proportion of individuals using at least one medication from each of these classes: hypoglycemics, antihypertensives and lipid-lowering agents. We identified the factors associated with the use of this combination of treatments by performing robust Poisson regressions. The 146,710 individuals used an average of 12 (SD 7) different medications, mostly cardiovascular (91.3% of users), hormones, including hypoglycemic agents (84.5%), and central nervous system medications (79.8%). The majority of individuals (59%) were exposed to the combination of treatments and the factor most strongly associated was the presence of cardiovascular comorbidities (RR: 1.29; 99% CI: 1.28-1.31). Older individuals with diabetes are exposed to a large number of medications. While the use of the combination of treatments is significant and could translate into cardiovascular benefits at the population level, the potential risk associated with polypharmacy needs to be documented.fr
dc.identifier.doi10.3390/pharmacy7040161fr
dc.identifier.issn2226-4787fr
dc.identifier.pubmed31805662fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/67721
dc.languageengfr
dc.publisherMDPI AGfr
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectMedicationfr
dc.subjectDiabetesfr
dc.subjectAgedfr
dc.subjectPharmacoepidemiologyfr
dc.subjectPolypharmacyfr
dc.subjectPopulation-based cohortfr
dc.subject.rvmPersonnes âgées -- Usage des médicamentsfr
dc.subject.rvmDiabète chez la personne âgéefr
dc.subject.rvmDiabétiques -- Usage des médicamentsfr
dc.subject.rvmPharmacologie gériatriquefr
dc.subject.rvmPolypharmaciefr
dc.titlePolypharmacy and pharmacological treatment of diabetes in older individuals : a population-based study in Quebec, Canadafr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationPharmacy, Vol. 7 (4), (2019)fr
dspace.accessstatus.time2023-01-28 18:02:59
dspace.entity.typePublication
relation.isAuthorOfPublication1c47e0c0-3666-4f68-a549-ec7445b7b398
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rioxxterms.project.funder-nameFonds de Recherche du Québec - Santéfr
rioxxterms.project.funder-nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder-nameCentre de Recherche sur les Soins et les Services de Première Ligne de l’Université Lavalfr
rioxxterms.project.funder-nameChaire de Recherche sur le Vieillissement de l’Université Lavalfr
rioxxterms.versionVoRfr
rioxxterms.version-of-recordhttps://doi.org/10.3390/pharmacy7040161fr
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