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Modulated response to cytokines of human wound healing myofibroblasts compared to dermal fibroblasts.

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bul.description.provenancenag spbfr
bul.rights.dateAccepPubl1998-01-10fr
bul.rights.periodeEmbargoforeverfr
bul.rights.raisonEmbargoInfiniPour que le document soit diffusé en libre accès, en accord avec le délai prescrit par l’éditeur de Experimental cell research, il faudrait déposer la version acceptée pour publication, incluant toutes les modifications demandées, mais sans la mise en page de la revue. Pour ce faire, effectuez une demande de modification à l’aide de la liste des dépôts diffusés à partir du tableau de suivi.fr
bul.rights.typeDatedatePublicationfr
dc.audience.peerreview1fr
dc.contributor.authorGermain, Lucie
dc.contributor.authorCastilloux, G.
dc.contributor.authorAuger, François A.
dc.contributor.authorGarrel, Dominique
dc.contributor.authorMoulin, Véronique
dc.contributor.authorO'Connor-McCourt, Maureen
dc.date.accessioned2018-01-24T19:18:00Z
dc.date.available9999-12-31
dc.date.issued1998-01-10
dc.description.abstractMyofibroblasts play an important role in normal wound healing. They are present transiently during tissue repair. Their differentiation from fibroblasts and their role in granulation tissues are most likely to be modulated by cytokines. As these cells are derived from normal fibroblasts, their responses to cytokines are assumed to be similar. Until now, however, the difficulties in obtaining and maintaining normal human wound healing myofibroblastsin vitrohave hampered comparison. The present study was designed to determine the effect of TGF-β1 and IFN-γ, two cytokines known to modulate fibroblast morphology, on wound healing myofibroblasts and to compare it to fibroblasts. Morphological and phenotypic changes were followed by light and electron microscopy (stress fibers) and immunofluorescence cytochemistry (α-SM actin). Functional parameters such as the capacity to synthesize collagen and collagen gel contraction were studied. Both cytokines induced a strong modification of growth rate and phenotypic and morphological parameters in fibroblasts whereas collagen synthesis was slightly changed. Furthermore, TGF-β1 increased contractile capacity of fibroblasts whereas IFN-γ greatly decreased it. In myofibroblasts, TGF-β1 and IFN-γ did not induce any variation of morphology or growth rate. Interestingly, a strong modulation of functional parameters was observed: collagen synthesis was highly modified and, as for fibroblasts, the contractile capacity was altered. However, inhibition of contraction by IFN-γ was irreversible in myofibroblasts but not in fibroblasts. These results suggest that fibroblastic cells show modulated responses to cytokines according to their stage of differentiation during wound healing.fr
dc.identifier.doi10.1006/excr.1997.3827fr
dc.identifier.issn00144827fr
dc.identifier.pubmed9457082fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/16559
dc.languageengfr
dc.publisherScienceDirectfr
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subjectskinfr
dc.subjectTransforming growth factor-βfr
dc.subjectinterferon-γfr
dc.subject.rvmMyofibroblastesfr
dc.subject.rvmFibroblastesfr
dc.subject.rvmFacteurs de croissance transformants bêtafr
dc.subject.rvmCytokinesfr
dc.subject.rvmCicatrisationfr
dc.subject.rvmInterféron de type IIfr
dc.titleModulated response to cytokines of human wound healing myofibroblasts compared to dermal fibroblasts.fr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationExperimental Cell Research, Vol. 238 (1), 283–293 (1998)fr
dspace.accessstatus.time2023-05-25 18:00:40
dspace.entity.typePublication
relation.isAuthorOfPublication375ce2c4-1171-4ecc-9901-7b68e028f911
relation.isAuthorOfPublication72ace9ee-08ce-4450-9b9c-f6690ff328fd
relation.isAuthorOfPublication978ec9c6-43e3-4ecb-8f9c-81c1c6b1062a
relation.isAuthorOfPublicatione60c26f0-355c-4a22-9655-7cd22caf2391
relation.isAuthorOfPublication.latestForDiscovery375ce2c4-1171-4ecc-9901-7b68e028f911
relation.isResourceTypeOfPublication4c433ef5-3937-4530-8252-cca17d715747
relation.isResourceTypeOfPublication.latestForDiscovery4c433ef5-3937-4530-8252-cca17d715747
rioxxterms.project.funder-nameHydro-Québecfr
rioxxterms.project.funder-nameRéseau des Grands Brûlés du Fonds de la Recherche en Santé du Québecfr
rioxxterms.project.funder-nameFondation des Pompiers du Québec pour Grands Brûlésfr
rioxxterms.project.funder-nameFondation de l’Hôpital du Saint-Sacrementfr
rioxxterms.versionVersion of Record (VoR)fr
rioxxterms.version-of-recordhttps://doi.org/10.1006/excr.1997.3827fr
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