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Publication :
Influence of the menstrual cycle on the timing of acute coronary events in premenopausal women.

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dc.contributor.authorHamelin, Bettina
dc.contributor.authorMéthot, Julie
dc.contributor.authorArsenault, Marie
dc.contributor.authorPilote, Sylvie
dc.contributor.authorPoirier, Paul
dc.contributor.authorPlante, Sylvain
dc.contributor.authorBogaty, Peter
dc.date.accessioned2022-12-07T21:16:49Z
dc.date.available2022-12-07T21:16:49Z
dc.date.issued2003-05-10
dc.description.abstractDuring their reproductive years, women have a low incidence of coronary artery disease, which increases markedly 10 to 15 years after menopause. It has long been hypothesized that this increased risk is at least in part due to the absence of female hormones, in particular, 17β-estradiol. This hypothesis was supported by data from epidemiological studies, which suggested that hormone replacement therapy would protect postmenopausal women from coronary artery disease. However, recent placebo-controlled trials designed to test the cardioprotective effects of a regimen of estrogens plus progestin have found no reduction in cardiovascular events or progression of angiographic lesions. Nevertheless, acute administration of 17β-estradiol affects the vasculature by modulating the nitric oxide–L-arginine pathway, and improves endothelial function and prolongs the time to ST-segment depression and exercise time, in postmenopausal women with coronary artery disease. These data suggest that the acute effects of 17β-estradiol could subside rapidly when levels are low during menses. Therefore, we sought to determine whether premenopausal women would be at greater risk of developing an acute coronary event when blood levels of 17β-estradiol levels are low during the menstrual cycle.
dc.identifier.doi10.1016/s0002-9343(03)00051-2
dc.identifier.issn0002-9343
dc.identifier.other12753884
dc.identifier.urihttp://hdl.handle.net/20.500.11794/105783
dc.languageeng
dc.language.isoen
dc.publisherNew York, NY : Excerpta Medica, Inc.
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subjectMenstrual cycleen_US
dc.subjectAcute coronaryen_US
dc.subjectEvents womenen_US
dc.subject17β-estradiolen_US
dc.subject.rvmCycle menstruel
dc.subject.rvmŒstradiol
dc.subject.rvmPériménopause
dc.subject.rvmArtères coronaires -- Maladies
dc.titleInfluence of the menstrual cycle on the timing of acute coronary events in premenopausal women.
dc.typearticle de recherche
dcterms.bibliographicCitationAmerican Journal of Medicine, Vol. 14 (7), 599-602 (2003)
dcterms.dateAccepted2002-11-27
dspace.accessstatus.time2024-03-19 18:00:37
dspace.entity.typePublication
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