Publication :
Design, degradation mechanism and long-term cytotoxicity of poly(L-lactide) and poly(lactide-co-ε-caprolactone) terpolymer film and air-spun nanofiber scaffold

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Date
2015-06-08
Auteurs
Larrañaga, Aitor
Fernandez, Jorge
Diéval, Florence
Durand, Bernard
Sarasua, Jose-Ramon
Direction de publication
Direction de recherche
Titre de la revue
ISSN de la revue
Titre du volume
Éditeur
Wiley Online Library
Projets de recherche
Structures organisationnelles
Numéro de revue
Résumé
Degradable nanofiber scaffold is known to provide a suitable, versatile and temporary structure for tissue regeneration. However, synthetic nanofiber scaffold must be properly designed to display appropriate tissue response during the degradation process. In this context, this publication focuses on the design of a finely-tuned poly(lactide-co-e-caprolactone) terpolymer (PLCL) that may be appropriate for vascular biomaterials applications and its comparison with well-known semi-crystalline poly(L-lactide) (PLLA). The degradation mechanism of polymer film and nanofiber scaffold and endothelial cells behavior cultured with degradation products is elucidated. The results highlight benefits of using PLCL terpolymer as vascular biomaterial compared to PLLA.
Description
Revue
Macromolecular bioscience, Vol. 15 (10), 1392–1410 (2015)
DOI
10.1002/mabi.201500130
URL vers la version publiée
Mots-clés
Nanofibers , Polylactide , Poly(lactide-co-ε-caprolactone) , Degradation , Tissue engineering , Vascular biomaterials
Citation
Type de document
article de recherche