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Heritability of LDL peak particle diameter in the Quebec Family Study

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bul.description.provenanceeb bde spbfr
bul.rights.dateAccepPubl2003-11-18fr
bul.rights.periodeEmbargoforeverfr
bul.rights.raisonEmbargoInfiniL’éditeur de Genetic epidemiology n’autorise pas la diffusion en libre accès dans un dépôt institutionnel.fr
bul.rights.typeDatedatePublicationfr
dc.contributor.authorBouchard, Claude
dc.contributor.authorPérusse, Louis
dc.contributor.authorLamarche, Benoît
dc.contributor.authorBossé, Yohan
dc.contributor.authorRice, Treva
dc.contributor.authorVohl, Marie-Claude
dc.contributor.authorRao, D. C. (Dabeeru C.)
dc.contributor.authorDesprés, Jean-Pierre
dc.date.accessioned2020-07-01T17:58:40Z
dc.date.available9999-12-31
dc.date.issued2003-11-18
dc.description.abstractLDL size has been associated with the risk of coronary heart disease. The objective of the present study was to verify whether familial factors influence LDL peak particle diameter (LDL‐PPD), a quantitative trait reflecting the size of the major LDL subclass. LDL‐PPD was measured by 2–16% polyacrylamide gradient gel electrophoresis in 681 members of 236 nuclear families participating in the Quebec Family Study. LDL‐PPD was adjusted for age (LDL‐PPD1), age and body mass index (LDL‐PPD2), or age, body mass index, and plasma triglyceride levels (LDL‐PPD3) separately in men and women. The residual scores were used to test for familial aggregation, using an ANOVA and to compute maximum likelihood estimates of familial correlations. The ANOVA test revealed that family lines accounted for 47.4%, 46.7%, and 48.9% of the variance in the LDL‐PPD1, LDL‐PPD2, and LDL‐PPD3 phenotypes, respectively. The pattern of familial correlations revealed no significant spouse correlations but significant parent‐offspring and sibling correlations for the three LDL‐PPD phenotypes, with maximal heritability estimates of 59%, 58%, and 52% for LDL‐PPD1, LDL‐PPD2, and LDL‐PPD3, respectively. These results suggest that LDL‐PPD strongly aggregates in families, and that the familial resemblance appears to be primarily attributable to genetic factors. Genes responsible for this genetic contribution remain to be identified. Genet Epidemiol 25:375–381, 2003. © 2003 Wiley‐Liss, Inc.fr
dc.identifier.doi10.1002/gepi.10272fr
dc.identifier.issn0741-0395fr
dc.identifier.pubmed14639707fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/39689
dc.languageengfr
dc.publisherWiley-Liss, Inc.fr
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subjectGeneticsfr
dc.subjectLipoproteinsfr
dc.subjectLDL sizefr
dc.subject.rvmLipoprotéines de basse densitéfr
dc.subject.rvmHéréditéfr
dc.titleHeritability of LDL peak particle diameter in the Quebec Family Studyfr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationGenetic epidemiology, Vol. 25 (4), 375–381 (2003)fr
dspace.accessstatus.time2023-05-24 18:06:11
dspace.entity.typePublication
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rioxxterms.projectMT-13960, MOP-14014, GR-15187fr
rioxxterms.project.funder-nameCanadian Institutes of Health Researchfr
rioxxterms.versionVersion of Record (VoR)fr
rioxxterms.version-of-recordhttps://doi.org/10.1002/gepi.10272fr
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