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Publication :
Shedding of microparticles by myofibroblasts as mediator of cellular cross-talk during normal wound healing

bul.description.provenanceeb spbfr
bul.rights.dateAccepPubl2010-06-07fr
bul.rights.periodeEmbargoP1Yfr
bul.rights.typeDatedatePublicationfr
dc.audienceMicrobiologistesfr
dc.audienceMédecinsfr
dc.audienceProfesseurs (Enseignement supérieur)fr
dc.audienceÉtudiantsfr
dc.audienceDoctorantsfr
dc.audience.peerreview1fr
dc.contributor.authorMessier, Hugo
dc.contributor.authorGenest, Hervé
dc.contributor.authorMoulin, Véronique
dc.contributor.authorMartinez, Maria Carmen
dc.contributor.authorMayrand, Dominique
dc.contributor.authorLopez-Vallé, Carlos Antonio
dc.date.accessioned2017-06-08T14:37:21Z
dc.date.available2017-06-08T14:37:21Z
dc.date.issued2010-06-07
dc.description.abstractInteractions between cells are a crucial mechanism to correctly heal a wounded tissue. Myofibroblasts have a central role during healing but their means to communicate with other cells is unknown. Microparticles (MP) have demonstrated a potential role as mediators of cellular interactions during various diseases. We have analyzed the production of MP by normal (Wmyo) and pathological (hypertrophic scar, Hmyo) myofibroblasts and human dermal fibroblasts (Fb) when treated with serum or plasma as examples of body fluids. We have shown that the presence of these body fluids induced a very significant increase in MP production by Wmyo while no MP production was denoted for Hmyo and Fb. These effects were at least due to thermally sensitive protein(s) with a molecular mass >30 kDa. Furthermore, the increase in MP production was not linked to an increase in apoptotic Wmyo. MP characterization showed that VEGF and FGF2 were present in MP and that endothelial and (myo)fibroblast cell growth can be stimulated by MP treatment. We postulated that MP production by myofibroblasts could modulate mesenchymal cell growth and angiogenesis during normal healing.fr
dc.identifier.doi10.1002/jcp.22268fr
dc.identifier.issn0021-9541fr
dc.identifier.pubmed20533304fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/14305
dc.languageengfr
dc.publisherLissfr
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectWound healingfr
dc.subjectMyofibroblastfr
dc.subjectMicroparticlefr
dc.subjectHypertrophic scarfr
dc.subjectFGFfr
dc.subjectVEGFfr
dc.subjectSerumfr
dc.subject.rvmMyofibroblastesfr
dc.subject.rvmCellules -- Interactionfr
dc.subject.rvmCicatrisationfr
dc.subject.rvmExosomesfr
dc.subject.rvmCicatrices hypertrophiquesfr
dc.subject.rvmFacteurs de croissance du fibroblastefr
dc.subject.rvmFacteurs de croissance des cellules endothéliales vasculairesfr
dc.titleShedding of microparticles by myofibroblasts as mediator of cellular cross-talk during normal wound healingfr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationJournal of Cellular Physiology, Vol. 225 (3), 734–740 (2010)fr
dspace.accessstatus.time2024-03-23 18:03:12
dspace.entity.typePublication
relation.isAuthorOfPublication5c0ac40e-95a7-457b-b4b7-0e643f22afbf
relation.isAuthorOfPublication78940844-1fd0-495f-ba3e-2e2656356e4e
relation.isAuthorOfPublicatione60c26f0-355c-4a22-9655-7cd22caf2391
relation.isAuthorOfPublicationfff97513-1ec7-4bfd-bf95-c0dc9b0fed2d
relation.isAuthorOfPublication.latestForDiscovery5c0ac40e-95a7-457b-b4b7-0e643f22afbf
relation.isResourceTypeOfPublication4c433ef5-3937-4530-8252-cca17d715747
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rioxxterms.project.funder-nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder-nameFonds de Recherche du Québec - Santéfr
rioxxterms.versionAccepted Manuscript (AM)fr
rioxxterms.version-of-recordhttps://doi.org/10.1002/jcp.22268fr

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