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GAD2 gene sequence variations are associated with eating behaviors and weight gain in women from the Quebec family study

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bul.description.provenanceec jgafr
bul.rights.dateAccepPubl2009-08-15fr
bul.rights.periodeEmbargoforeverfr
bul.rights.raisonEmbargoInfiniPour que le document soit diffusé en libre accès, en accord avec le délai prescrit par l’éditeur de Physiology and Behaviours, il faudrait déposer la version acceptée pour publication, incluant toutes les modifications demandées, mais sans la mise en page de la revue. Pour ce faire, effectuez une demande de modification à l’aide de la liste des dépôts diffusés à partir du tableau de suivi.fr
bul.rights.typeDatedatePublicationfr
dc.audienceProfesseurs (Enseignement supérieur)fr
dc.audienceÉtudiantsfr
dc.audienceDoctorantsfr
dc.contributor.authorDrapeau, Vicky
dc.contributor.authorChoquette, Anne.
dc.contributor.authorBouchard, Claude
dc.contributor.authorPérusse, Louis
dc.contributor.authorTremblay, Angelo
dc.contributor.authorLemieux, Simone
dc.contributor.authorVohl, Marie-Claude
dc.coverage.spatialQuébec (Province)fr
dc.date.accessioned2017-09-14T18:55:46Z
dc.date.available9999-12-31
dc.date.issued2009-08-15
dc.description.abstractThe glutamate decarboxylase 2 (GAD2) gene encodes for the glutamic acid decarboxylase enzyme (GAD65), which is implicated in the formation of the gamma-aminobutyric acid (GABA), a neurotransmitter involved in the regulation of food intake. The objective of the present study was to test for association between GAD2 single-nucleotide polymorphisms (SNPs) and eating behaviors, dietary intake and obesity in subjects (n=873) from the Quebec Family Study (QFS). Energy and macronutrient intakes were measured using a 3-day dietary record and eating behaviors were assessed using the Three-Factor Eating Questionnaire (TFEQ). Six SNPs capturing about 90% of GAD2 gene variability were genotyped and tested for association with age- and BMI- adjusted phenotypes. No evidence of association was found in men. In women, a SNP (rs992990; c.61450 C>A) was associated with disinhibition (p=0.028), emotional susceptibility to disinhibition (p=0.0005) and susceptibility to hunger (p=0.028). Another SNP (rs7908975; c.8473A>C) was associated with carbohydrate (p=0.021) and lipid (p=0.021) intakes, disinhibition (p=0.011) and two of its subscales (emotional and situational susceptibility) as well as with avoidance of fattening foods (p=0.036). Six-year weight gain was two times higher in women carrying the variants associated with eating behaviors: 4.2kg (vs 2.1kg in non-carriers) in A-allele carriers of c.61450 C>A (p=0.038) and 4.9kg (vs 2.5kg in non-carriers) in C-allele carriers of c. 8473 A>C (p=0.013). The results suggest a role for the GAD2 gene in determining food intake, eating behaviors and weight gain over time in women.en
dc.identifier.doi10.1016/j.physbeh.2009.08.004fr
dc.identifier.issn0031-9384fr
dc.identifier.pubmed19686769fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/15390
dc.languageengfr
dc.publisherPergamon Pressfr
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subjectGAD2fr
dc.subjectEating behaviorsfr
dc.subjectDietary intakesfr
dc.subjectObesityfr
dc.subject.rvmObésité chez la femmefr
dc.subject.rvmHabitudes alimentairesfr
dc.subject.rvmGlutamate décarboxylasefr
dc.titleGAD2 gene sequence variations are associated with eating behaviors and weight gain in women from the Quebec family studyfr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationPhysiology and Behaviours, Vol. 98 (4), 505–510 (2009)fr
dspace.accessstatus.time2023-03-26 18:05:02
dspace.entity.typePublication
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rioxxterms.project.funder-nameMedical Research Council Canadafr
rioxxterms.project.funder-nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder-nameGeorge A. Bray Chair in Nutritionfr
rioxxterms.versionVoRfr
rioxxterms.version-of-recordhttps://doi.org/10.1016/j.physbeh.2009.08.004fr
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