Publication :
Air-spun PLA nanofibers modified with reductively-sheddable hydrophilic surfaces for vascular tissue engineering : synthesis and surface modification

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bul.description.provenancemcp spbfr
bul.rights.dateAccepPubl2013-09-23fr
bul.rights.periodeEmbargoP1Yfr
bul.rights.typeDatedatePublicationfr
dc.contributor.authorNa, Re Ko
dc.contributor.authorLaroche, Gaétan
dc.contributor.authorSabbatier, Gad
dc.contributor.authorCunningham, Alexander J.
dc.contributor.authorOh, Jung Kwon
dc.date.accessioned2019-07-23T13:06:56Z
dc.date.available2019-07-23T13:06:56Z
dc.date.issued2013-09-23
dc.description.abstractPolylactide (PLA) is a class of promising biomaterials that hold great promise for various biological and biomedical applications, particularly in the field of vascular tissue engineering where it can be used as a fibrous mesh to coat the inside of vascular prostheses. However, its hydrophobic surface providing nonspecific interactions and its limited ability to further modifications are challenges that need to be overcome. Here, the development of new air-spun PLA nanofibers modified with hydrophilic surfaces exhibiting reduction response is reported. Surface-initiated atom transfer radical polymerization allows for grafting pendant oligo(ethylene oxide)-containing polymethacrylate (POEOMA) from PLA air-spun fibers labeled with disulfide linkages. The resulting PLA-ss-POEOMA fibers exhibit enhanced thermal stability and improved surface properties, as well as thiol-responsive shedding of hydrophilic POEOMA by the cleavage of its disulfide linkages in response to reductive reactions, thus tuning the surface properties.fr
dc.identifier.doi10.1002/marc.201300609fr
dc.identifier.issn1022-1336fr
dc.identifier.pubmed24089393fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/35593
dc.languageengfr
dc.publisherJohn Wiley & Sonsfr
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectAir-spinningfr
dc.subjectAtom transfer radical polymerizationfr
dc.subjectPolylactidefr
dc.subjectRing-opening polymerizationfr
dc.subjectThiol-disulfide degradationfr
dc.subject.rvmAcide polylactiquefr
dc.subject.rvmPolymérisation par ouverture de cyclefr
dc.subject.rvmPolymérisationfr
dc.subject.rvmNanofibresfr
dc.subject.rvmGénie tissulairefr
dc.subject.rvmPolymères hydrophilesfr
dc.titleAir-spun PLA nanofibers modified with reductively-sheddable hydrophilic surfaces for vascular tissue engineering : synthesis and surface modificationfr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationMacromolecular rapid communications, Vol. 35 (4), 447-453 (Feb. 2014)fr
dspace.accessstatus.time2023-01-26 18:03:13
dspace.entity.typePublication
relation.isAuthorOfPublication7207871e-32e9-4680-a0f1-6ce126aebe57
relation.isAuthorOfPublicationf988d57e-6c71-4358-83fa-113331686855
relation.isAuthorOfPublication.latestForDiscovery7207871e-32e9-4680-a0f1-6ce126aebe57
relation.isResourceTypeOfPublication4c433ef5-3937-4530-8252-cca17d715747
relation.isResourceTypeOfPublication.latestForDiscovery4c433ef5-3937-4530-8252-cca17d715747
rioxxterms.project.funder-nameNatural Sciences and Engineering Research Council of Canadafr
rioxxterms.project.funder-nameFonds Québécois de la Recherche sur la Nature et les Technologiesfr
rioxxterms.versionAMfr
rioxxterms.version-of-recordhttp://dx.doi.org/10.1002/marc.201300609fr
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