Publication :
Air-spun PLA nanofibers modified with reductively-sheddable hydrophilic surfaces for vascular tissue engineering : synthesis and surface modification

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Date
2013-09-23
Auteurs
Na, Re Ko
Cunningham, Alexander J.
Oh, Jung Kwon
Direction de publication
Direction de recherche
Titre de la revue
ISSN de la revue
Titre du volume
Éditeur
John Wiley & Sons
Projets de recherche
Structures organisationnelles
Numéro de revue
Résumé
Polylactide (PLA) is a class of promising biomaterials that hold great promise for various biological and biomedical applications, particularly in the field of vascular tissue engineering where it can be used as a fibrous mesh to coat the inside of vascular prostheses. However, its hydrophobic surface providing nonspecific interactions and its limited ability to further modifications are challenges that need to be overcome. Here, the development of new air-spun PLA nanofibers modified with hydrophilic surfaces exhibiting reduction response is reported. Surface-initiated atom transfer radical polymerization allows for grafting pendant oligo(ethylene oxide)-containing polymethacrylate (POEOMA) from PLA air-spun fibers labeled with disulfide linkages. The resulting PLA-ss-POEOMA fibers exhibit enhanced thermal stability and improved surface properties, as well as thiol-responsive shedding of hydrophilic POEOMA by the cleavage of its disulfide linkages in response to reductive reactions, thus tuning the surface properties.
Description
Revue
Macromolecular rapid communications, Vol. 35 (4), 447-453 (Feb. 2014)
DOI
10.1002/marc.201300609
URL vers la version publiée
Mots-clés
Air-spinning , Atom transfer radical polymerization , Polylactide , Ring-opening polymerization , Thiol-disulfide degradation
Citation
Type de document
article de recherche