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Tissue engineering of skin and cornea : Development of new models for in vitro studies

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bul.description.provenanceeb spbfr
bul.rights.dateAccepPubl2010-06-02fr
bul.rights.periodeEmbargoforeverfr
bul.rights.raisonEmbargoInfiniPour que le document soit diffusé en libre accès, en accord avec le délai prescrit par l’éditeur de Annals of the New York Academy of Sciences, il faudrait déposer la version acceptée pour publication, incluant toutes les modifications demandées, mais sans la mise en page de la revue. Pour ce faire, effectuez une demande de modification à l’aide de la liste des dépôts diffusés à partir du tableau de suivi.fr
bul.rights.typeDatedatePublicationfr
dc.audience.peerreview1fr
dc.contributor.authorGuérin, Sylvain
dc.contributor.authorGermain, Lucie
dc.contributor.authorLarouche, Danielle
dc.contributor.authorBisson, Francis
dc.contributor.authorPaquet, Claudie
dc.contributor.authorRobitaille, Hubert
dc.contributor.authorAuger, François A.
dc.contributor.authorGaudreault, Manon.
dc.contributor.authorMartel, Israël
dc.contributor.authorDuranceau, Louise
dc.contributor.authorProulx, Stéphanie
dc.contributor.authorCarrier, Patrick
dc.contributor.authorSimard-Bisson, Carolyne
dc.contributor.authorFradette, Julie
dc.date.accessioned2018-01-29T21:29:19Z
dc.date.available9999-12-31
dc.date.issued2010-06-02
dc.description.abstractHuman beings are greatly preoccupied with the unavoidable nature of aging. While the biological processes of senescence and aging are the subjects of intense investigations, the molecular mechanisms linking aging with disease and death are yet to be elucidated. Tissue engineering offers new models to study the various processes associated with aging. Using keratin 19 as a stem cell marker, our studies have revealed that stem cells are preserved in human skin reconstructed by tissue engineering and that the number of epithelial stem cells varies according to the donor's age. As with skin, human corneas can also be engineered in vitro. Among the epithelial cells used for reconstructing skin and corneas, significant age-dependent variations in the expression of the transcription factor Sp1 were observed. Culturing skin epithelial cells with a feeder layer extended their life span in culture, likely by preventing Sp1 degradation in epithelial cells, therefore demonstrating the pivotal role played by this transcription factor in cell proliferation. Finally, using the human tissue-engineered skin as a model, we linked Hsp27 activation with skin differentiation.fr
dc.identifier.doi10.1111/j.1749-6632.2009.05373.xfr
dc.identifier.issn0077-8923fr
dc.identifier.pubmed20536846fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/16747
dc.languageengfr
dc.publisherAcademy of Sciencesfr
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subjectTissue engineeringfr
dc.subjectSkinfr
dc.subjectCorneafr
dc.subjectStem cellfr
dc.subjectK19fr
dc.subjectSp1fr
dc.subjectHsp27fr
dc.subjectAgingfr
dc.subjectDifferentiationfr
dc.subject.rvmGénie tissulairefr
dc.subject.rvmCornée -- Cultures et milieux de culturefr
dc.subject.rvmPeau -- Cultures et milieux de culturefr
dc.subject.rvmVieillissementfr
dc.titleTissue engineering of skin and cornea : Development of new models for in vitro studiesfr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationAnnals of the New York Academy of Sciences, Vol. 1197 (1), 166–177 (2010)fr
dspace.accessstatus.time2023-01-26 18:03:00
dspace.entity.typePublication
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rioxxterms.project.funder-nameCanadian Institutes of Health Researchfr
rioxxterms.versionVoRfr
rioxxterms.version-of-recordhttps://doi.org/10.1111/j.1749-6632.2009.05373.xfr
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