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Mechanism of potentiation by polyphenols of contraction in human vein-engineered media

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bul.description.provenancelf spbfr
bul.rights.dateAccepPubl2005-06-01fr
bul.rights.periodeEmbargoforeverfr
bul.rights.raisonEmbargoInfiniPour que le document soit diffusé en libre accès, en accord avec le délai prescrit par l’éditeur de American journal of physiology. Heart and circulatory physiology, il faudrait déposer la version acceptée pour publication, incluant toutes les modifications demandées, mais sans la mise en page de la revue. Pour ce faire, effectuez une demande de modification à l’aide de la liste des dépôts diffusés à partir du tableau de suivi.fr
bul.rights.typeDatedatePublicationfr
dc.audience.peerreview1fr
dc.contributor.authorGermain, Lucie
dc.contributor.authorDiebolt, Myriam
dc.contributor.authorAuger, François A.
dc.contributor.authorAndriantsitohaina, Ramaroson
dc.date.accessioned2018-01-26T20:27:30Z
dc.date.available9999-12-31
dc.date.issued2005-06-01
dc.description.abstractThe potential of natural dietary polyphenols in the treatment of vascular diseases originating from veins has been suggested in the literature. However, the mechanisms involved to explain the effects of polyphenols are not yet elucidated. Therefore, the aim of this study was to investigate the mechanisms by which polyphenols from red wine (Provinols) modulated contraction in human veins. We took advantage of a human model previously reported as a new tool for pharmacological research, using tissue-engineered techniques allowing the production of vascular media based exclusively on human smooth muscle cells. Thus human tissue-engineered vascular media (TEVM) were produced with cells originating from umbilical cord vein. TEVM were treated with either vehicle or Provinols. Results showed that treatment of TEVM with Provinols significantly potentiated the contractile responses induced by histamine and bradykinin. The potentiating effect of Provinols was not associated with an enhancement of histamine-induced increase in cytosolic calcium; rather, it implied the presence of a Ca(2+)-independent signaling pathway. Pharmacological studies indicated that action of Provinols took place at the level of phospholipase A(2)-Rho-kinase pathway and was associated with an enhancement of myosin light chain kinase activity. These results, obtained using the human TEVM, bring new insights to explain the regulation of venous contraction by polyphenols.fr
dc.identifier.doi10.1152/ajpheart.01194.2004fr
dc.identifier.issn0363-6135fr
dc.identifier.pubmed15665048fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/16695
dc.languageengfr
dc.publisherAmerican Physiological Societyfr
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subjectTissue engineeringfr
dc.subjectVeinsfr
dc.subjectSmooth musclefr
dc.subject.rvmGénie tissulairefr
dc.subject.rvmPolyphénolsfr
dc.subject.rvmVaisseaux sanguinsfr
dc.subject.rvmCellules musculaires lissesfr
dc.titleMechanism of potentiation by polyphenols of contraction in human vein-engineered mediafr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationAmerican journal of physiology. Heart and circulatory physiology, Vol. 288 (6), H2918-H2924 (2005)fr
dspace.accessstatus.time2023-03-26 18:03:30
dspace.entity.typePublication
relation.isAuthorOfPublication375ce2c4-1171-4ecc-9901-7b68e028f911
relation.isAuthorOfPublication382995aa-95b5-4428-a1ad-0a1a5e7ddc4e
relation.isAuthorOfPublication978ec9c6-43e3-4ecb-8f9c-81c1c6b1062a
relation.isAuthorOfPublication.latestForDiscovery375ce2c4-1171-4ecc-9901-7b68e028f911
relation.isResourceTypeOfPublication4c433ef5-3937-4530-8252-cca17d715747
relation.isResourceTypeOfPublication.latestForDiscovery4c433ef5-3937-4530-8252-cca17d715747
rioxxterms.project.funder-nameSociété Française de Distilleriesfr
rioxxterms.project.funder-nameCentre National de la Recherche Scientifique (Ingénierie Tissulaire)fr
rioxxterms.project.funder-nameCanadian Institutes of Health Researchfr
rioxxterms.versionVoRfr
rioxxterms.version-of-recordhttps://doi.org/10.1152/ajpheart.01194.2004fr
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