Publication :
Network Analysis of the potential role of DNA methylation in the relationship between plasma carotenoids and lipid profile

En cours de chargement...
Vignette d'image
Date
2019-06-04
Direction de publication
Direction de recherche
Titre de la revue
ISSN de la revue
Titre du volume
Éditeur
MDPI
Projets de recherche
Structures organisationnelles
Numéro de revue
Résumé

Abstract: Variability in plasma carotenoids may be attributable to several factors including genetic variants and lipid profile. Until now, the impact of DNA methylation on this variability has not been widely studied. Weighted gene correlation network analysis (WGCNA) is a systems biology method used for finding gene clusters (modules) with highly correlated methylation levels and for relating them to phenotypic traits. The objective of the present study was to examine the role of DNA methylation in the relationship between plasma total carotenoid concentrations and lipid profile using WGCNA in 48 healthy subjects. Genome-wide DNA methylation levels of 20,687 out of 472,245 CpG sites in blood leukocytes were associated with total carotenoid concentrations. Using WGCNA, nine co-methylation modules were identified. A total of 2734 hub genes (17 unique top hub genes) were potentially related to lipid profile. This study provides evidence for the potential implications of gene co-methylation in the relationship between plasma carotenoids and lipid profile. Further studies and validation of the hub genes are needed.

Description
Revue
Nutrients, 11 (6), 1-14(2019)
DOI
10.3390/nu11061265
URL vers la version publiée
Mots-clés
Carotenoids , DNA methylation , French canadians , Hub genes , Lipid profile , WGCNA
Citation
Type de document
article de recherche