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Expression of heat shock proteins in mouse skin during wound healing

bul.description.provenancelf spbfr
bul.rights.dateAccepPubl1998-11-01fr
bul.rights.periodeEmbargoforeverfr
bul.rights.raisonEmbargoInfiniPour que le document soit diffusé en libre accès, en accord avec le délai prescrit par l’éditeur de The journal of histochemistry and cytochemistry, il faudrait déposer la version acceptée pour publication, incluant toutes les modifications demandées, mais sans la mise en page de la revue. Pour ce faire, effectuez une demande de modification à l’aide de la liste des dépôts diffusés à partir du tableau de suivi.fr
bul.rights.typeDatedatePublicationfr
dc.audience.peerreview1fr
dc.contributor.authorLandry, Jacques
dc.contributor.authorLaplante, Alain F.
dc.contributor.authorLi, Hui
dc.contributor.authorGermain, Lucie
dc.contributor.authorMorrow, Geneviève
dc.contributor.authorTanguay, Robert
dc.contributor.authorAuger, François A.
dc.contributor.authorMoulin, Véronique
dc.date.accessioned2018-01-23T20:38:02Z
dc.date.available9999-12-31
dc.date.issued1998-11-01
dc.description.abstractWound healing conditions generate a stressful environment for the cells involved in the regeneration process and are therefore postulated to influence the expression of heat shock proteins (Hsps). We have examined the expression of four Hsps (Hsp27, Hsp60, Hsp70 and Hsp90) and a keratin (keratin 6) by immunohistochemistry during cutaneous wound repair from Day 1 to Day 21 after wounding in the mouse. Hsps were constitutively expressed in normal mouse epidermis and their patterns of expression were modified during the healing process. The changes were not directly linked to the time course of the healing process but rather were dependent on the location of cells in the regenerating epidermis. In the thickened epidermis, Hsp60 was induced in basal and low suprabasal cells, Hsp70 showed a reduced expression, and Hsp90 and Hsp27 preserved a suprabasal pattern with an induction in basal and low suprabasal cells. All Hsps had a uniform pattern of expression in the migrating epithelial tongue. These observations suggest that the expression of Hsps in the neoepidermis is related to the proliferation, the migration, and the differentiation states of keratinocytes within the wound.fr
dc.identifier.doi10.1177/002215549804601109fr
dc.identifier.issn0022-1554fr
dc.identifier.pubmed9774628fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/16578
dc.languageengfr
dc.publisherWilliams & Wilkins Co.fr
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subjectWound healingfr
dc.subjectEpidermisfr
dc.subjectKeratinocytesfr
dc.subjectSkinfr
dc.subjectMicefr
dc.subjectKeratinfr
dc.subjectHeat shock proteinsfr
dc.subjectMolecular chaperonesfr
dc.subjectImmunohistochemistryfr
dc.subject.rvmCicatrisation -- Modèles animauxfr
dc.subject.rvmSouris (Animal de laboratoire)fr
dc.subject.rvmÉpidermefr
dc.subject.rvmKératinocytesfr
dc.subject.rvmProtéines de choc thermiquefr
dc.subject.rvmKératinefr
dc.subject.rvmMolécules chaperonnesfr
dc.subject.rvmImmunocytochimiefr
dc.titleExpression of heat shock proteins in mouse skin during wound healingfr
dc.typearticle de recherche
dc.type.legacyCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationThe journal of histochemistry and cytochemistry, Vol. 46 (11), 1291-1301 (1998)fr
dspace.accessstatus.time2023-03-11 18:00:54
dspace.entity.typePublication
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rioxxterms.project.funder-nameMedical Research Council Canadafr
rioxxterms.project.funder-nameFonds de Recherche du Québec - Santéfr
rioxxterms.versionVoRfr
rioxxterms.version-of-recordhttps://doi.org/10.1177/002215549804601109fr
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