Publication :
Expression of heat shock proteins in mouse skin during wound healing

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Date
1998-11-01
Direction de publication
Direction de recherche
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Éditeur
Williams & Wilkins Co.
Projets de recherche
Structures organisationnelles
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Résumé
Wound healing conditions generate a stressful environment for the cells involved in the regeneration process and are therefore postulated to influence the expression of heat shock proteins (Hsps). We have examined the expression of four Hsps (Hsp27, Hsp60, Hsp70 and Hsp90) and a keratin (keratin 6) by immunohistochemistry during cutaneous wound repair from Day 1 to Day 21 after wounding in the mouse. Hsps were constitutively expressed in normal mouse epidermis and their patterns of expression were modified during the healing process. The changes were not directly linked to the time course of the healing process but rather were dependent on the location of cells in the regenerating epidermis. In the thickened epidermis, Hsp60 was induced in basal and low suprabasal cells, Hsp70 showed a reduced expression, and Hsp90 and Hsp27 preserved a suprabasal pattern with an induction in basal and low suprabasal cells. All Hsps had a uniform pattern of expression in the migrating epithelial tongue. These observations suggest that the expression of Hsps in the neoepidermis is related to the proliferation, the migration, and the differentiation states of keratinocytes within the wound.
Description
Revue
The journal of histochemistry and cytochemistry, Vol. 46 (11), 1291-1301 (1998)
DOI
10.1177/002215549804601109
URL vers la version publiée
Mots-clés
Wound healing , Epidermis , Keratinocytes , Skin , Mice , Keratin , Heat shock proteins , Molecular chaperones , Immunohistochemistry
Citation
Type de document
article de recherche