Personne : Sabbatier, Gad
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Sabbatier
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Gad
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Département de génie des mines, de la métallurgie et des matériaux, Faculté des sciences et de génie, Université Laval
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ncf11882388
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Publication Accès libre Design, degradation mechanism and long-term cytotoxicity of poly(L-lactide) and poly(lactide-co-ε-caprolactone) terpolymer film and air-spun nanofiber scaffold(Wiley Online Library, 2015-06-08) Laroche, Gaétan; Larrañaga, Aitor; Guay-Bégin, Andrée-Anne; Sabbatier, Gad; Fernandez, Jorge; Diéval, Florence; Durand, Bernard; Sarasua, Jose-RamonDegradable nanofiber scaffold is known to provide a suitable, versatile and temporary structure for tissue regeneration. However, synthetic nanofiber scaffold must be properly designed to display appropriate tissue response during the degradation process. In this context, this publication focuses on the design of a finely-tuned poly(lactide-co-e-caprolactone) terpolymer (PLCL) that may be appropriate for vascular biomaterials applications and its comparison with well-known semi-crystalline poly(L-lactide) (PLLA). The degradation mechanism of polymer film and nanofiber scaffold and endothelial cells behavior cultured with degradation products is elucidated. The results highlight benefits of using PLCL terpolymer as vascular biomaterial compared to PLLA.Publication Accès libre Air-spun PLA nanofibers modified with reductively-sheddable hydrophilic surfaces for vascular tissue engineering : synthesis and surface modification(John Wiley & Sons, 2013-09-23) Na, Re Ko; Laroche, Gaétan; Sabbatier, Gad; Cunningham, Alexander J.; Oh, Jung KwonPolylactide (PLA) is a class of promising biomaterials that hold great promise for various biological and biomedical applications, particularly in the field of vascular tissue engineering where it can be used as a fibrous mesh to coat the inside of vascular prostheses. However, its hydrophobic surface providing nonspecific interactions and its limited ability to further modifications are challenges that need to be overcome. Here, the development of new air-spun PLA nanofibers modified with hydrophilic surfaces exhibiting reduction response is reported. Surface-initiated atom transfer radical polymerization allows for grafting pendant oligo(ethylene oxide)-containing polymethacrylate (POEOMA) from PLA air-spun fibers labeled with disulfide linkages. The resulting PLA-ss-POEOMA fibers exhibit enhanced thermal stability and improved surface properties, as well as thiol-responsive shedding of hydrophilic POEOMA by the cleavage of its disulfide linkages in response to reductive reactions, thus tuning the surface properties.