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Robitaille, Julie

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Robitaille

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Julie

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Université Laval. Institut sur la nutrition et les aliments fonctionnels

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  • PublicationRestreint
    Features of the metabolic syndrome are modulated by an interaction between the PPAR-delta –87T>C polymorphism and dietary fat in French-Canadians
    (Stockton Press, 2006-09-05) Pérusse, Louis; Gaudet, Daniel; Vohl, Marie-Claude; Robitaille, Julie
    Objective: We verified whether genetic variants in this gene are associated with the MS and whether dietary fatty acids interact with the −87T>C polymorphism. Methods: By direct sequencing, we identified 15 variants in the PPAR-delta gene and analyses were pursued with the −87T>C polymorphism for 340 subjects. Results: Metabolic variables were comparable among each genotype group. The −87T>C polymorphism, fat intake and the interaction accounted, respectively for 2.2, 1.9 and 1.5% of the variance in high-density lipoprotein cholesterol (HDL-C) levels (P<0.05) (age, sex and energy intake were included into the model). The total cholesterol/HDL-C ratio was also modulated by a gene–diet interaction and by the –87T>C polymorphism (P<0.05). No gene–diet interaction effects were observed for other features of the MS. The age- and sex-adjusted odds ratio (OR) of exhibiting three or more features of the MS when carrying the −87C allele was 0.62 (P=0.04) compared to –87T/T. However, in subjects consuming less than 34.4% of energy from fat (median of fat consumption), the OR in carriers of the −87C allele was of 0.42 (P=0.008).
  • PublicationAccès libre
    Social support for healthy eating : development and validation of a questionnaire for the French-Canadian population
    (CAB International, 2018-05-28) Carbonneau, Élise; Corneau, Louise; Bradette-Laplante, Maude; Lamarche, Benoît; Lemieux, Simone; Vohl, Marie-Claude; Robitaille, Julie; Desroches, Sophie; Bégin, Catherine; Provencher, Véronique
    Objective: The present study aimed to develop and validate a questionnaire assessing social support for healthy eating in a French-Canadian population. Design: A twenty-one-item questionnaire was developed. For each item, participants were asked to rate the frequency, in the past month, with which the actions described had been done by family and friends in two different environments: (i) at home and (ii) outside of home. The content was evaluated by an expert panel. A validation study sample was recruited and completed the questionnaire twice. Exploratory factor analysis was performed on items to assess the number of subscales. Internal consistency reliability was assessed using Cronbach's ɑ. Test-retest reliability was evaluated with intraclass correlations between scores of the two completions. Setting: Online survey. Subjects: Men and women from the Québec City area (n 150). Results: The content validity assessment led to a few changes, resulting in a twenty-two-item questionnaire. Exploratory factor analysis revealed a two-factor structure for both environments, resulting in four subscales: supportive actions at home; non-supportive actions at home; supportive actions outside of home; and non-supportive actions outside of home. Two items were removed from the questionnaire due to low loadings. The four subscales were found to be reliable (Cronbach's ɑ=0·82-0·94; test-retest intraclass correlation=0·51-0·70). Conclusions: The Social Support for Healthy Eating Questionnaire was developed for a French-Canadian population and demonstrated good psychometric properties. This questionnaire will be useful to explore the role of social support and its interactions with other factors in predicting eating behaviours.
  • PublicationAccès libre
    Social support for healthy eating : development and validation of a questionnaire for the French-Canadian population
    (CAB International, 2018-05-28) Carbonneau, Élise; Corneau, Louise; Bradette-Laplante, Maude; Lamarche, Benoît; Lemieux, Simone; Vohl, Marie-Claude; Robitaille, Julie; Desroches, Sophie; Bégin, Catherine; Provencher, Véronique
    Objective: The present study aimed to develop and validate a questionnaire assessing social support for healthy eating in a French-Canadian population. Design: A twenty-one-item questionnaire was developed. For each item, participants were asked to rate the frequency, in the past month, with which the actions described had been done by family and friends in two different environments: (i) at home and (ii) outside of home. The content was evaluated by an expert panel. A validation study sample was recruited and completed the questionnaire twice. Exploratory factor analysis was performed on items to assess the number of subscales. Internal consistency reliability was assessed using Cronbach’s ɑ. Test–retest reliability was evaluated with intraclass correlations between scores of the two completions. Setting: Online survey. Subjects: Men and women from the Québec City area (n 150). Results: The content validity assessment led to a few changes, resulting in a twenty-two-item questionnaire. Exploratory factor analysis revealed a two-factor structure for both environments, resulting in four subscales: supportive actions at home; non-supportive actions at home; supportive actions outside of home; and non-supportive actions outside of home. Two items were removed from the questionnaire due to low loadings. The four subscales were found to be reliable (Cronbach’s ɑ=0·82–0·94; test–retest intraclass correlation=0·51–0·70). Conclusions: The Social Support for Healthy Eating Questionnaire was developed for a French-Canadian population and demonstrated good psychometric properties. This questionnaire will be useful to explore the role of social support and its interactions with other factors in predicting eating behaviours.
  • PublicationRestreint
    Molecular screening of the 11β-HSD1 gene in men characterized by the metabolic syndrome
    (Wiley, 2012-09-06) Brouillette, Charles; Houde, Alain; Vohl, Marie-Claude; Després, Jean-Pierre; Robitaille, Julie; Tchernof, André
    Adipose tissue type 1 11β‐hydroxysteroid dehydrogenase (11β‐HSD1), which generates hormonally active cortisol from inactive cortisone, has been shown to play a central role in adipocyte differentiation and abdominal obesity‐related metabolic complications. The objective was to investigate whether genetic variations in the human 11 β‐HSD1 gene are associated with the metabolic syndrome among French‐Canadian men. We sequenced all exons, the exon‐intron splicing boundaries, and 5′ and 3′ regions of the human 11 β‐HSD1 gene in 36 men with the metabolic syndrome, as defined by the National Cholesterol Education Program‐Adult Treatment Panel III, and two controls. Three intronic sequence variants were identified: two single‐nucleotide polymorphisms in intron 3 (g.4478T>G) and intron 4 (g.10733G>C) and one insertion in intron 3 (g.4437‐4438insA). The relative allele frequency was 19.6%, 22.1%, and 19.6% for the g.4478G, g.10733C, and g.4438insA alleles, respectively. One single‐nucleotide polymorphism was identified in exon 6 (c.744G>C or G248G). The frequency of the c.744C allele was only 0.46% in a sample of 217 men. Variants were not associated with components of the metabolic syndrome except for plasma apolipoprotein B levels. In conclusion, molecular screening of the 11 β‐HSD1 gene did not reveal any sequence variations that can significantly contribute to the etiology of the metabolic syndrome among French‐Canadians.
  • PublicationAccès libre
    Are French Canadians able to accurately self-rate the quality of their diet? Insights from the PREDISE study
    (National Research Council Canada, 2018-08-29) Carbonneau, Élise; Corneau, Louise; Lamarche, Benoît; Lafrenière, Jacynthe; Lemieux, Simone; Robitaille, Julie; Desroches, Sophie; Provencher, Véronique
    Cette étude se propose principalement de comparer l’autoévaluation de la qualité du régime alimentaire à un score de qualité nutritionnelle globale et à évaluer la prédictibilité de l’autoévaluation concernant l’adhésion aux recommandations de saine alimentation. Cette étude examine aussi la possible influence des caractéristiques individuelles sur l’association entre l’autoévaluation du régime alimentaire et le score de qualité nutritionnelle globale. Dans le cadre du projet PRédicteurs Individuels, Sociaux et Environnementaux (PREDISE), 1045 participants (51 % femmes) du Québec (Canada) ont autoévalué la qualité de leur régime alimentaire (« En général, diriez-vous que vos habitudes alimentaires sont : excellentes, très bonnes, bonnes, passables ou mauvaises? »). Les données de trois rappels alimentaires de 24 h via Internet ont permis le calcul du Healthy Eating Index (C-HEI), un indicateur de qualité nutritionnelle globale. Les participants percevaient leurs habitudes alimentaires comme étant excellentes (2,4 %), très bonnes (22,7 %), bonnes (49,5 %), passables (20,3 %) ou mauvaises (5,1 %). Le C-HEI variait significativement entre les catégories d’autoévaluation dans la direction attendue (p < 0,0001). L’autoévaluation a permis de prédire l’adhésion aux recommandations (C-HEI > 68) de saine alimentation en présentant une sensibilité de 44,5 % et une spécificité de 81,5 % (statistique C = 0,63). L’association entre l’autoévaluation et le C-HEI était modifiée significativement par le sexe (p interaction = 0,0131); les femmes avaient un C-HEI plus élevé que les hommes dans les catégories « bonnes » et « passables ». L’autoévaluation du régime alimentaire permet de donner un aperçu de la qualité du régime alimentaire d’une population. Cependant, les résultats de cette étude suggèrent d’utiliser ces données avec prudence compte tenu de leur faible prédictibilité concernant l’adhésion aux recommandations de saine alimentation. Des caractéristiques individuelles sont susceptibles d’influencer l’aptitude à autoévaluer adéquatement la qualité du régime alimentaire.
  • PublicationAccès libre
    The lipoprotein/lipid profile is modulated by a gene–diet interaction effect between polymorphisms in the liver X receptor-α and dietary cholesterol intake in French-Canadians
    (Cambridge University Press, 2007-01-01) Pérusse, Louis; Gaudet, Daniel; Lemieux, Simone; Houde, Alain; Vohl, Marie-Claude; Robitaille, Julie
    Genetic and nutritional factors interact together and modulate the plasma lipid profile. We identified variations in the gene encoding the liver X receptor α (LXRα) and investigated their effects on the plasma lipoprotein/lipid profile. We also examined whether the association between cholesterol intake and plasma lipid profile was modulated by LXRα variants. The LXRα gene was sequenced in thirty-five French-Canadian men with high plasma total cholesterol (>5·0 mmol/l) and LDL-cholesterol (>3·5 mmol/l) concentrations. Dietary cholesterol was obtained from a food-frequency questionnaire. The LXRα c.-115G>A, c.-840C>A and c.-1830T>C genotypes were determined by direct sequencing in 732 subjects. Molecular screening of the LXRα gene revealed sixteen variants. Genotypes c.-115G>A, c.-840C>A and c.-1830T>C (rare allele frequency of 14·3 %, 14·2 % and 11·0 %, respectively) were analysed further. Plasma total cholesterol concentrations were higher in carriers of the -115A, -840A and -1830C allele, compared with the -115G/G, -840C/C and -1830T/T homozygotes (P ≤ 0·05). In a model including the c.-115G>A polymorphism, cholesterol intake, the interaction term c.-115G>A × cholesterol intake (mg/d) and covariates, LXRα-115G>A explained 1·8 % and 2·1 % of the variance in total cholesterol and LDL-cholesterol concentrations (P = 0·02 and P = 0·01), whereas the interaction term explained 2·9 % (P = 0·002) and 2·8 % (P = 0·005), respectively. When subjects were divided into four groups according to the median of cholesterol (290·8 mg) and -115G>A genotypes, high cholesterol intake was associated with higher cholesterol levels in -115A carriers. Similar results were observed for c.-840C>A and c.-1830T>C. These results suggest that cholesterol intake interacts with LXRα variants to modulate the plasma lipid profile.
  • PublicationAccès libre
    Development and validation of a nutrition knowledge questionnaire for a Canadian population
    (CABI Pub., 2016-12-27) Bradette-Laplante, Maude (***); Lemieux, Simone; Carbonneau, Élise (***); Vohl, Marie-Claude; Robitaille, Julie; Bégin, Catherine; Provencher, Véronique; Desroches, Sophie (***); Corneau, Louise (***)
    Objective The present study aimed to develop and validate a nutrition knowledge questionnaire in a sample of French Canadians from the province of Quebec, taking into account dietary guidelines. Design A thirty-eight-item questionnaire was developed by the research team and evaluated for content validity by an expert panel, and then administered to respondents. Face validity and construct validity were measured in a pre-test. Exploratory factor analysis and covariance structure analysis were performed to verify the structure of the questionnaire and identify problematic items. Internal consistency and test–retest reliability were evaluated through a validation study. Setting Online survey. Subjects Six nutrition and psychology experts, fifteen registered dietitians (RD) and 180 lay people participated. Results Content validity evaluation resulted in the removal of two items and reformulation of one item. Following face validity, one item was reformulated. Construct validity was found to be adequate, with higher scores for RD v. non-RD (21·5 (sd 2·1) v. 15·7 (sd 3·0) out of 24, P<0·001). Exploratory factor analysis revealed that the questionnaire contained only one factor. Covariance structure analysis led to removal of sixteen items. Internal consistency for the overall questionnaire was adequate (Cronbach’s α=0·73). Assessment of test–retest reliability resulted in significant associations for the total knowledge score (r=0·59, P<0·001). Conclusions This nutrition knowledge questionnaire was found to be a suitable instrument which can be used to measure levels of nutrition knowledge in a Canadian population. It could also serve as a model for the development of similar instruments in other populations.
  • PublicationAccès libre
    Development of a web-based 24-h dietary recall for a french-canadian population
    (MDPI Pub., 2016-11-15) Jacques, Simon; Tessier-Grenier, Maude; Lapointe, Annie; Corneau, Louise; Lamarche, Benoît; Laramée, Catherine; Lemieux, Simone; Robitaille, Julie
    Twenty-four-hour dietary recalls can provide high-quality dietary intake data, but are considered expensive, as they rely on trained professionals for both their administration and coding. The objective of this study was to develop an automated, self-administered web-based 24-h recall (R24W) for a French-Canadian population. The development of R24W was inspired by the United States Department of Agriculture (USDA) Automated Multiple-Pass Method. Questions about the context of meals/snacks were included. Toppings, sauces and spices frequently added to each food/dish were suggested systematically. A list of frequently forgotten food was also suggested. An interactive summary allows the respondent to track the progress of the questionnaire and to modify or remove food as needed. The R24W prototype was pre-tested for usability and functionality in a convenience sample of 29 subjects between the ages of 23 and 65 years, who had to complete one recall, as well as a satisfaction questionnaire. R24W includes a list of 2865 food items, distributed into 16 categories and 98 subcategories. A total of 687 recipes were created for mixed dishes, including 336 ethnic recipes. Pictures of food items illustrate up to eight servings per food item. The pre-test demonstrated that R24W is easy to complete and to understand. This new dietary assessment tool is a simple and inexpensive tool that will facilitate diet assessment of individuals in large-scale studies, but validation studies are needed prior to the utilization of the R24W.
  • PublicationRestreint
    Plasma concentrations of apoprotein B are modulated by a gene-diet interaction effect between the LFABP T94A polymorphism and dietary fat intake in French-Canadian men
    (Elsevier, 2004-07-02) Brouillette, Charles; Pérusse, Louis; Gaudet, Daniel; Lemieux, Simone; Vohl, Marie-Claude; Robitaille, Julie
    Hyperapobetalipoproteinemia is a common feature of the metabolic syndrome and could result from the interaction between genetic and dietary factors. The objective of this study was to verify whether dietary fat intake interacts with the T94A polymorphism of the liver fatty acid-binding protein (LFABP) gene to modulate plasma apolipoprotein (apo) B levels. Dietary fat and saturated fat intakes were obtained by a dietitian-administered food frequency questionnaire and the LFABP T94A genotype was determined by a PCR-RFLP based method in 623 French-Canadian men recruited through the Chicoutimi Lipid Clinic (279 T94/T94, 285 T94/A94, and 59 A94/A94). The LFABP T94A polymorphism was not associated with plasma apo B levels when fat intake was not taken into consideration. However, in a model including the polymorphism, fat intake expressed as a percentage of total energy intake, the interaction term and covariates, the variance in apo B concentrations was partly explained by the LFABP T94A polymorphism (5.24%, p=0.01) and by the LFABP T94A ∗ fat interaction (6.25%, p=0.005). Results were similar when saturated fat replaced fat intake in the model (4.49%, p=0.02 for LFABP T94A and 6.43%, p=0.004 for the interaction). Moreover, in men consuming more than 30% of energy from fat, the odds ratio for having plasma apo B levels above 1.04 g/L for A94 carriers was of 0.40 (p=0.02) compared to T94/T94 homozygotes. Results were similar for carriers of the A94 allele consuming more than 10% of energy from saturated fat (OR: 0.32, p=0.005). In conclusion, T94/T94 exhibit higher apo B levels whereas carriers of the A94 allele seem to be protected against high apo B levels when consuming a high fat and saturated fat diet. These findings reinforce the importance to take into account gene–diet interactions in the prevention and management of the metabolic syndrome.